Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity.
Serum uric acid does not predict incident metabolic syndrome in a population with high prevalence of obesity.
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DOI：
10.1016/j.numecd.2014.06.002
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
de Simone G
中科院分区：
文献类型：
--
作者：
Ferrara LA;Wang H;Umans JG;Franceschini N;Jolly S;Lee ET;Yeh J;Devereux RB;Howard BV;de Simone G
评估尿酸 (UA) 是否可以预测强心脏研究 (SHS) 队列中非糖尿病参与者的代谢综合征 (MetS) 4 年发病率。在这项基于人群的前瞻性研究中，我们分析了 1499 名没有糖尿病或 MetS 的美国印第安人（890 名女性），他们在第四次 SHS 检查期间进行了控制，并在 4 年后在第五次 SHS 检查期间进行了重新检查。参与者被分为 UA 的性别特异性三分位数，并将前两个三分位数（N 组）与第三个三分位数（H 组）进行比较。 H组的体重指数（BMI = 28.3±7 vs. 31.1±7 kg/m2）、去脂体重（FFM = 52.0±14 vs. 54.9±11 kg）、腰臀比、HOMA-IR（3.66 vs. 4.26）、血压和炎症指数均显着高于N组（均p<0.001）。 H 组第 5 次检查时的 MetS 事件比 N 组更频繁（35 vs. 28%，OR 1.44（95% CI=1.10-1.91；p< 0.01）。这种关联仍然显着（OR= 1.13，p=0.04），与家庭关系、性别、高血压病史、HOMA-IR、中心性肥胖和肾功能无关，但在无脂肪时消失在 SHS 中，UA 水平与胰岛素抵抗参数和炎症指数相关，但不能独立于初始肥胖相关增加的 FFM 来预测 MetS 事件。
To evaluate whether uric acid (UA) predicts 4-yr incidence of metabolic syndrome (MetS) in non-diabetic participants of the Strong Heart Study (SHS) cohort. In this population-based prospective study we analyzed 1499 American Indians (890 women), without diabetes or MetS, controlled during the 4th SHS exam and reexamined 4 years later during the 5th SHS exam. Participants were divided into sex-specific tertiles of UA and the first two tertiles (group N) were compared with the third tertile (group H). Body mass index (BMI =28.3±7 vs. 31.1±7 kg/m2), fat-free mass (FFM = 52.0±14 vs. 54.9±11 kg), waist-to-hip ratio, HOMA-IR (3.66 vs. 4.26), BP and indices of inflammation were significantly higher in group H than in group N (all p<0.001). Incident MetS at the time of the 5th exam was more frequent in group H than group N (35 vs. 28%, OR 1.44 (95% CI=1.10-1.91; p< 0.01). This association was still significant (OR= 1.13, p=0.04) independently of family relatedness, sex, history of hypertension, HOMA-IR, central adiposity and renal function, but disappeared when fat-free mass was included in the model. In the SHS, UA levels are associated to parameters of insulin resistance and to indices of inflammation. UA levels, however, do not predict incident MetS independently of the initial obesity-related increased FFM.
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影响因子：
7.1
作者：
STOLARCZYK, LM;HEYWARD, VH;BAUMGARTNER, RN
通讯作者：
BAUMGARTNER, RN
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
8.2
作者：
MATTHEWS, DR;HOSKER, JP;TURNER, RC
通讯作者：
TURNER, RC
影响因子：
3.3
作者：
Johnson, Richard J.;Lanaspa, Miguel A.;Gaucher, Eric A.
通讯作者：
Gaucher, Eric A.