Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.
Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.
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DOI：
10.1016/j.semnephrol.2011.08.002
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发表时间：
2011-09
影响因子：
3.3
通讯作者：
Gaucher, Eric A.
中科院分区：
文献类型：
--
作者：
Johnson, Richard J.;Lanaspa, Miguel A.;Gaucher, Eric A.
所有人类都被尿酸酶敲除；由于大约 1500 万年前中新世中期发生的突变，我们失去了尿酸酶基因。尿酸酶敲除的结果是我们的血清尿酸水平较高，且不易调节，并且很容易受到饮食的影响。这会增加我们患痛风和肾结石的风险，但也有越来越多的证据表明尿酸会增加我们患高血压、肾病、肥胖和糖尿病的风险。这就提出了为什么会发生这种突变的问题。在本文中，我们回顾了当前的假设。我们认为尿酸是从 RNA 世界传递过来的危险和生存信号。中新世食物短缺和全球变冷期间发生的尿酸酶突变为早期灵长类动物带来了生存优势，尤其是在欧洲。如今，尿酸酶的缺失起到了节俭基因的作用，增加了我们患肥胖和心肾疾病的风险。
All humans are uricase knockouts; we lost the uricase gene due to a mutation that occurred in the mid Miocene approximately 15 million years ago. The consequence of being a uricase knockout is that we have higher serum uric acid levels that are less regulatable and can be readily influenced by diet. This increases our risk for gout and kidney stones, but there is also increasing evidence that uric acid increases our risk for hypertension, kidney disease, obesity and diabetes. This raises the question of why this mutation occurred. In this paper we review current hypotheses. We suggest that uric acid is a danger and survival signal carried over from the RNA world. The mutation of uricase that occurred during the food shortage and global cooling that occurred in the Miocene resulted in a survival advantage for early primates, particularly in Europe. Today, the loss of uricase functions as a thrifty gene, increasing our risk for obesity and cardiorenal disease.
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影响因子：
7.4
作者：
Hellsten, Y;Tullson, PC;Bangsbo, J
通讯作者：
Bangsbo, J
DOI：
10.1007/bf01796514
发表时间：
1990-12-17
期刊：
KLINISCHE WOCHENSCHRIFT
影响因子：
--
作者：
GRESSER, U;GATHOF, B;ZOLLNER, N
通讯作者：
ZOLLNER, N
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
120.7
作者：
Fang, J;Alderman, MH
通讯作者：
Alderman, MH
影响因子：
4.9
作者：
Corry, Dalila B.;Eslami, Pirooz;Tuck, Michael L.
通讯作者：
Tuck, Michael L.