Divergence in cortical representations of threat generalization in affective versus perceptual circuitry in childhood: Relations with anxiety.
Divergence in cortical representations of threat generalization in affective versus perceptual circuitry in childhood: Relations with anxiety.
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DOI：
10.1016/j.neuropsychologia.2020.107416
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发表时间：
2020-05
期刊：
影响因子：
2.6
通讯作者：
Michalska KJ
中科院分区：
文献类型：
--
作者：
Glenn DE;Fox NA;Pine DS;Peters MAK;Michalska KJ
Children at risk for anxiety display elevated threat sensitivity and may inaccurately classify safe stimuli as threatening, a process known as overgeneralization. Little is known about whether such overgeneralization might stem from altered sensory representations of stimuli resembling threat, especially in youth. Here we implement representational similarity analysis of fMRI data to examine the similarity of neural representations of threat versus ambiguous or safe stimuli in threat and perceptual neurocircuitry among children at varying levels of anxiety traits. Three weeks after completing threat conditioning and extinction, children underwent an fMRI extinction recall task, during which they viewed the extinguished threat cue (CS+), safety cue (CS−) and generalization stimuli (GS) consisting of CS−/CS+ blends. Multivoxel BOLD signal patterns were measured in seven regions of interest: four affective areas (ventromedial prefrontal cortex (vmPFC), anterior insular cortex (AIC), dorsomedial prefrontal cortex (dmPFC), and amygdala) and three perceptual areas (inferior temporal cortex (ITC) and visual areas V1 and V4). Compared to low anxious children, children with high trait anxiety evidenced less neural pattern differentiation between the CS+ and similar GS, particularly in the vmPFC. Together, these results demonstrate the utility of multivariate neuroimaging approaches in arbitrating the relative contributions of perceptual versus affective sources to threat generalization.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
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DOI：
10.1097/00004583-199704000-00018
发表时间：
1997-04-01
影响因子：
13.3
作者：
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通讯作者：
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影响因子：
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