Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.
Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.
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DOI：
10.1016/j.mcn.2011.06.013
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发表时间：
2011-12
影响因子：
3.5
通讯作者：
Winckler, Bettina
中科院分区：
文献类型：
--
作者：
Lasiecka, Zofia M.;Winckler, Bettina
关键词：
神经元是极化细胞，具有复杂而独特的形态：长的突起（轴突和树突）从细胞体延伸很远。此外，体树突和轴突结构域进一步分为特定的亚结构域，如突触（突触前和突触后特化），近端和远端树突，轴突起始段，朗维尔结和轴突生长锥。神经元细胞的显著不对称性和复杂性是其接收、处理和传递电信号的功能所必需的，每个域在这些过程中发挥着精确的功能。为了建立和维持不同的神经元结构域，必须存在将蛋白质递送到特定神经元隔室的机制，使得每个隔室具有正确的功能分子组成。如何建立和维持极化膜域是一个长期存在的问题。跨膜蛋白，如受体和粘附分子，可以通过几种途径运输到它们适当的膜结构域。生物合成分泌系统将新合成的跨膜蛋白从ER-高尔基体通过trans-Golgi网络（TGN）递送到质膜。此外，内体系统在许多情况下关键地参与确保膜组分的适当（重新）靶向，因为它可以内化和降解错误定位的蛋白质，或将蛋白质从一个结构域再循环到另一个结构域。因此，内体系统对于建立和维持神经元极性至关重要。在这篇综述中，我们主要集中在细胞内室，作为分选站的极化运输，特别强调的新兴作用的内涵体。
Neurons are polarized cells that have a complex and unique morphology: long processes (axons and dendrites) extending far from the cell body. In addition, the somatodendritic and axonal domains are further divided into specific subdomains, such as synapses (pre- and postsynaptic specializations), proximal and distal dendrites, axon initial segments, nodes of Ranvier, and axon growth cones. The striking asymmetry and complexity of neuronal cells is necessary for their function in receiving, processing and transferring electrical signals, with each domain playing a precise function in these processes. In order to establish and maintain distinct neuronal domains, mechanisms must exist for protein delivery to specific neuronal compartments, such that each compartment has the correct functional molecular composition. How polarized membrane domains are established and maintained is a long-standing question. Transmembrane proteins, such as receptors and adhesion molecules, can be transported to their proper membrane domains by several pathways. The biosynthetic secretory system delivers newly synthesized transmembrane proteins from the ER-Golgi via the trans-Golgi network (TGN) to the plasma membrane. In addition, the endosomal system is critically involved in many instances in ensuring proper (re)targeting of membrane components because it can internalize and degrade mislocalized proteins, or recycle proteins from one domain to another. The endosomal system is thus crucial for establishing and maintaining neuronal polarity. In this review, we focus mainly on the intracellular compartments that serve as sorting stations for polarized transport, with particular emphasis on the emerging roles of endosomes.
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影响因子：
4
作者：
Bel, Christophe;Oguievetskaia, Ksenia;Faivre-Sarrailh, Catherine
通讯作者：
Faivre-Sarrailh, Catherine
影响因子：
7.5
作者：
Folsch, Heike
通讯作者：
Folsch, Heike
影响因子：
64.5
作者：
DOTTI, CG;SIMONS, K
通讯作者：
SIMONS, K
DOI：
10.1523/jneurosci.1542-09.2009
发表时间：
2009-09-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Ascaño M;Richmond A;Borden P;Kuruvilla R
通讯作者：
Kuruvilla R
DOI：
10.1083/jcb.200408165
发表时间：
2004-11-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ang AL;Taguchi T;Francis S;Fölsch H;Murrells LJ;Pypaert M;Warren G;Mellman I
通讯作者：
Mellman I