Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience.
Hypothalamic Regulation of Corticotropin-Releasing Factor under Stress and Stress Resilience.
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DOI：
10.3390/ijms222212242
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发表时间：
2021-11-12
影响因子：
5.6
通讯作者：
Daimon M
中科院分区：
文献类型：
--
作者：
Kageyama K;Iwasaki Y;Daimon M
本文综述了应激和应激恢复下丘脑促肾上腺皮质激素释放因子（CRF）调节的分子机制。下丘脑中的CRF在调节应激反应中起着重要作用。CRF刺激促肾上腺皮质激素（ACTH）从垂体前叶释放。ACTH刺激肾上腺分泌糖皮质激素。糖皮质激素对压力应对、压力恢复和体内平衡至关重要。下丘脑-垂体-肾上腺轴的激活受到糖皮质激素负反馈的抑制。cAMP刺激的Crf启动子活性的糖皮质激素依赖性抑制由负糖皮质激素反应元件和血清反应元件介导。相反，诱导型cAMP早期阻遏物可以通过抑制cAMP依赖性Crf基因来抑制应激反应，下丘脑中细胞因子信号传导-3的抑制物也可以。1型CRF受体主要参与应激反应、抑郁、厌食和癫痫发作，而2型CRF受体介导“应激应对”机制，如大脑中的抗焦虑作用。FK 506结合亲免素FKBP 4和FKBP 5的差异效应有助于糖皮质激素在应激恢复下的效率。总之，各种因素有助于压力恢复。所有这些因素在压力恢复力下都有不同的作用。
This review addresses the molecular mechanisms of corticotropin-releasing factor (CRF) regulation in the hypothalamus under stress and stress resilience. CRF in the hypothalamus plays a central role in regulating the stress response. CRF stimulates adrenocorticotropic hormone (ACTH) release from the anterior pituitary. ACTH stimulates glucocorticoid secretion from the adrenal glands. Glucocorticoids are essential for stress coping, stress resilience, and homeostasis. The activated hypothalamic-pituitary-adrenal axis is suppressed by the negative feedback from glucocorticoids. Glucocorticoid-dependent repression of cAMP-stimulated Crf promoter activity is mediated by both the negative glucocorticoid response element and the serum response element. Conversely, the inducible cAMP-early repressor can suppress the stress response via inhibition of the cAMP-dependent Crf gene, as can the suppressor of cytokine signaling-3 in the hypothalamus. CRF receptor type 1 is mainly involved in a stress response, depression, anorexia, and seizure, while CRF receptor type 2 mediates “stress coping” mechanisms such as anxiolysis in the brain. Differential effects of FK506-binding immunophilins, FKBP4 and FKBP5, contribute to the efficiency of glucocorticoids under stress resilience. Together, a variety of factors contribute to stress resilience. All these factors would have the differential roles under stress resilience.
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影响因子：
16.2
作者：
CHANG, CP;PEARSE, RV;ROSENFELD, MG
通讯作者：
ROSENFELD, MG
伴侣FKBP5塑造了雄性小鼠下丘脑室室核中急性应激反应。
影响因子：
11
作者：
Häusl AS;Brix LM;Hartmann J;Pöhlmann ML;Lopez JP;Menegaz D;Brivio E;Engelhardt C;Roeh S;Bajaj T;Rudolph L;Stoffel R;Hafner K;Goss HM;Reul JMHM;Deussing JM;Eder M;Ressler KJ;Gassen NC;Chen A;Schmidt MV
通讯作者：
Schmidt MV
DOI：
10.1056/nejmra1802337
发表时间：
2021-02-11
期刊：
The New England journal of medicine
影响因子：
--
作者：
Allada R;Bass J
通讯作者：
Bass J
影响因子：
4.8
作者：
Gatto, Federico;Feelders, Richard;Hofland, Leo J.
通讯作者：
Hofland, Leo J.
影响因子：
2.9
作者：
Angeles Garcia-Leon, Maria;Manuel Perez-Marmol, Jose;Isabel Peralta-Ramirez, Maria
通讯作者：
Isabel Peralta-Ramirez, Maria