Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway.
Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway.
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DOI：
10.3389/fimmu.2021.680503
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发表时间：
2021
影响因子：
7.3
通讯作者：
Pouget JP
中科院分区：
文献类型：
--
作者：
Constanzo J;Faget J;Ursino C;Badie C;Pouget JP
在过去的十年中，放射治疗（RT）进入了个性化医疗时代，在放射输送和治疗计划优化方面取得了显着进步，并在理解癌症反应（包括免疫反应）方面取得了显着进步。下一个挑战是确定诱导临床相关抗肿瘤免疫应答的最佳放射方案。危险器官和肿瘤微环境（例如内皮细胞、巨噬细胞和成纤维细胞）通常会因不良毒性而限制放射治疗方案的效果。在这里，我们综述了RT如何调节参与肿瘤控制的免疫反应以及与炎症过程相关的副作用。此外，我们讨论了RT期间肿瘤微环境成分的多功能作用，RT诱导的遗传毒性的先天免疫感应如何通过cGAS-STING途径将抗肿瘤免疫反应，辐射诱导的坏死和辐射诱导的纤维化联系起来，以及如何更好地理解有利和有害事件之间的转换可能有助于定义创新方法来增加癌症患者的RT益处。
In the past decade, radiation therapy (RT) entered the era of personalized medicine, following the striking improvements in radiation delivery and treatment planning optimization, and in the understanding of the cancer response, including the immunological response. The next challenge is to identify the optimal radiation regimen(s) to induce a clinically relevant anti-tumor immunity response. Organs at risks and the tumor microenvironment (e.g. endothelial cells, macrophages and fibroblasts) often limit the radiation regimen effects due to adverse toxicities. Here, we reviewed how RT can modulate the immune response involved in the tumor control and side effects associated with inflammatory processes. Moreover, we discussed the versatile roles of tumor microenvironment components during RT, how the innate immune sensing of RT-induced genotoxicity, through the cGAS-STING pathway, might link the anti-tumor immune response, radiation-induced necrosis and radiation-induced fibrosis, and how a better understanding of the switch between favorable and deleterious events might help to define innovative approaches to increase RT benefits in patients with cancer.
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影响因子：
3.6
作者：
Baskar R;Lee KA;Yeo R;Yeoh KW
通讯作者：
Yeoh KW
影响因子：
6.2
作者：
Azria, D.;Betz, M.;Ozsahin, M.
通讯作者：
Ozsahin, M.
DOI：
10.1073/pnas.011417098
发表时间：
2001-01-16
影响因子：
11.1
作者：
Azzam, EI;de Toledo, SM;Little, JB
通讯作者：
Little, JB
影响因子：
9.3
作者：
Bergsma, Hendrik;van Lom, Kirsten;Kwekkeboom, Dik J.
通讯作者：
Kwekkeboom, Dik J.
影响因子：
1.9
作者：
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通讯作者：
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