A pH-responsive T(1)-T(2) dual-modal MRI contrast agent for cancer imaging.
A pH-responsive T(1)-T(2) dual-modal MRI contrast agent for cancer imaging.
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pH响应性t（1）-t（2）癌症成像的双模式MRI对比剂。
DOI：
10.1038/s41467-022-35655-x
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发表时间：
2022-12-26
影响因子：
16.6
通讯作者：
Tian, Leilei
中科院分区：
文献类型：
--
作者：
Lu, Hongwei;Chen, An;Zhang, Xindan;Wei, Zixiang;Cao, Rong;Zhu, Yi;Lu, Jingxiong;Wang, Zhongling;Tian, Leilei
磁共振成像（MRI）是一种用于诊断健康状况的非侵入性成像技术，但其灵敏度较低。本文合成了一种造影剂SPIO@SiO2@MnO2，该造影剂在正常生理条件下T1和T2造影剂强度降低。在肿瘤或炎症组织的酸性环境中，二氧化锰（MnO2）层分解成具有磁性活性的Mn2+ （T1加权），T1和T2信号依次恢复。此外，超顺磁氧化铁（SPIO）和MnO2之间的二氧化硅（SiO2）中间层可以精确调节T1和T2图像的对比淬火活化程度。通过“双对比增强减影”成像处理技术，将该MRI造影剂的对比灵敏度提高到病变组织与正常组织的12.3倍之差。因此，SPIO@SiO2@MnO2成功地用于追踪约0.5 mm的微小肝转移并监测组织炎症。磁共振成像（MRI）是一种成熟的无创医学成像技术。在这里，为了提高该技术的性能，作者描述了一种ph响应T1-T2双峰MRI造影剂的设计，在临床前癌症模型中显示出增强的成像敏感性。
Magnetic resonance imaging (MRI) is a non-invasive imaging technology to diagnose health conditions, showing the weakness of low sensitivity. Herein, we synthesize a contrast agent, SPIO@SiO2@MnO2, which shows decreased T1 and T2 contrast intensity in normal physiological conditions. In the acid environment of tumor or inflamed tissue, the manganese dioxide (MnO2) layer decomposes into magnetically active Mn2+ (T1-weighted), and the T1 and T2 signals are sequentially recovered. In addition, both constrast quenching-activation degrees of T1 and T2 images can be accurately regulated by the silicon dioxide (SiO2) intermediate layer between superparamagnetic iron oxide (SPIO) and MnO2. Through the “dual-contrast enhanced subtraction” imaging processing technique, the contrast sensitivity of this MRI contrast agent is enhanced to a 12.3-time difference between diseased and normal tissue. Consequently, SPIO@SiO2@MnO2 is successfully applied to trace the tiny liver metastases of approximately 0.5 mm and monitor tissue inflammation. Magnetic resonance imaging (MRI) is a well-established non-invasive medical imaging technology. Here, to improve the performance of the technique, the authors describe the design of a pH-responsive T1-T2 dual-modal MRI contrast agent, showing enhanced imaging sensitivity in preclinical cancer models.
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影响因子：
16.6
作者：
Braig D;Nero TL;Koch HG;Kaiser B;Wang X;Thiele JR;Morton CJ;Zeller J;Kiefer J;Potempa LA;Mellett NA;Miles LA;Du XJ;Meikle PJ;Huber-Lang M;Stark GB;Parker MW;Peter K;Eisenhardt SU
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DOI：
10.1002/anie.202100885
发表时间：
2021-05-03
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
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作者：
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通讯作者：
Stasiuk GJ
影响因子：
13.3
作者：
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影响因子：
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作者：
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通讯作者：
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