Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh.
Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh.
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DOI：
10.1093/infdis/jiaa101
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发表时间：
2021-10-13
期刊：
影响因子：
--
通讯作者：
Lee B
中科院分区：
文献类型：
--
作者：
Williams FB;Kader A;Colgate ER;Dickson DM;Carmolli M;Uddin MI;Sharmin S;Islam S;Bhuiyan TR;Alam M;Nayak U;Mychaleckyj JC;Petri WA;Haque R;Qadri F;Kirkpatrick BD;Lee B
Secretor status controls mucosal histo–blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.
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DOI：
10.1093/infdis/jiy054
发表时间：
2018-04-11
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Lee B;Dickson DM;deCamp AC;Ross Colgate E;Diehl SA;Uddin MI;Sharmin S;Islam S;Bhuiyan TR;Alam M;Nayak U;Mychaleckyj JC;Taniuchi M;Petri WA Jr;Haque R;Qadri F;Kirkpatrick BD
通讯作者：
Kirkpatrick BD
影响因子：
6.4
作者：
Kazi, Abdul Momin;Cortese, Margaret M.;Ali, Asad
通讯作者：
Ali, Asad
影响因子：
3
作者：
Silva, Lara M.;Carvalho, Ana S.;David, Leonor
通讯作者：
David, Leonor
影响因子：
15.5
作者：
Lewis ZT;Totten SM;Smilowitz JT;Popovic M;Parker E;Lemay DG;Van Tassell ML;Miller MJ;Jin YS;German JB;Lebrilla CB;Mills DA
通讯作者：
Mills DA
影响因子：
11.8
作者：
Tate, Jacqueline E.;Burton, Anthony H.;Parashar, Umesh D.
通讯作者：
Parashar, Umesh D.