Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants.
Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants.
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DOI：
10.1186/s40168-015-0071-z
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发表时间：
2015
期刊：
影响因子：
15.5
通讯作者：
Mills DA
中科院分区：
文献类型：
--
作者：
Lewis ZT;Totten SM;Smilowitz JT;Popovic M;Parker E;Lemay DG;Van Tassell ML;Miller MJ;Jin YS;German JB;Lebrilla CB;Mills DA
具有岩藻糖基转移酶2基因（FUT 2;称为“分泌”基因）的失活等位基因的个体在许多人群中很常见。已知双歧杆菌属的一些成员（常见的婴儿肠道菌）消耗分泌型母亲母乳中发现的2′-岩藻糖基化聚糖。我们研究了母体分泌状态对发育中的婴儿微生物群的影响，特别强调了生物多样性细菌物种丰度。平均而言，分泌型母亲喂养的婴儿比非分泌型母亲喂养的婴儿更早和更频繁地建立双歧杆菌。在分泌型喂养的婴儿中，长双歧杆菌群的相对丰度与双歧杆菌目的高百分比最强相关。相反，在非分泌型喂养的婴儿中，短双歧杆菌与双歧杆菌属细菌呈正相关，而B。longum组呈负相关。从分泌性喂养的婴儿中分离出的双歧杆菌消耗2′-岩藻糖基乳糖的百分比较高。具有高水平双歧杆菌的婴儿粪便中的乳寡糖水平较低，乳酸盐含量较高。此外，粪便中含有不同的双歧杆菌物种具有不同量的寡糖，表明差异消费原位。由非分泌型母亲喂养的婴儿在建立充满生物多样性细菌的微生物群方面延迟。这种延迟可能是由于婴儿难以获得一种能够消耗母亲提供的特定乳寡糖的双歧杆菌。这项工作提供了关于牛奶聚糖如何富集婴儿体内特定有益细菌种群的机理见解，并揭示了在风险人群（如早产儿）中增强益生菌种群富集的线索。本文的在线版本（doi：10.1186/s40168-015-0071-z）包含补充材料，可供授权用户使用。
Individuals with inactive alleles of the fucosyltransferase 2 gene (FUT2; termed the ‘secretor’ gene) are common in many populations. Some members of the genus Bifidobacterium, common infant gut commensals, are known to consume 2′-fucosylated glycans found in the breast milk of secretor mothers. We investigated the effects of maternal secretor status on the developing infant microbiota with a special emphasis on bifidobacterial species abundance. On average, bifidobacteria were established earlier and more often in infants fed by secretor mothers than in infants fed by non-secretor mothers. In secretor-fed infants, the relative abundance of the Bifidobacterium longum group was most strongly correlated with high percentages of the order Bifidobacteriales. Conversely, in non-secretor-fed infants, Bifidobacterium breve was positively correlated with Bifidobacteriales, while the B. longum group was negatively correlated. A higher percentage of bifidobacteria isolated from secretor-fed infants consumed 2′-fucosyllactose. Infant feces with high levels of bifidobacteria had lower milk oligosaccharide levels in the feces and higher amounts of lactate. Furthermore, feces containing different bifidobacterial species possessed differing amounts of oligosaccharides, suggesting differential consumption in situ. Infants fed by non-secretor mothers are delayed in the establishment of a bifidobacteria-laden microbiota. This delay may be due to difficulties in the infant acquiring a species of bifidobacteria able to consume the specific milk oligosaccharides delivered by the mother. This work provides mechanistic insight into how milk glycans enrich specific beneficial bacterial populations in infants and reveals clues for enhancing enrichment of bifidobacterial populations in at risk populations - such as premature infants. The online version of this article (doi:10.1186/s40168-015-0071-z) contains supplementary material, which is available to authorized users.
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影响因子：
2.3
作者：
Andriantsoanirina, Valerie;Allano, Solene;Aires, Julio
通讯作者：
Aires, Julio
影响因子：
6.3
作者：
Bauer, Jacqueline;Gerss, Joachim
通讯作者：
Gerss, Joachim
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM
DOI：
10.1073/pnas.1000080107
发表时间：
2011-03-15
影响因子：
11.1
作者：
Caporaso, J. Gregory;Lauber, Christian L.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
4.4
作者：
De Leoz ML;Gaerlan SC;Strum JS;Dimapasoc LM;Mirmiran M;Tancredi DJ;Smilowitz JT;Kalanetra KM;Mills DA;German JB;Lebrilla CB;Underwood MA
通讯作者：
Underwood MA