Meta-analysis of the association between SCARB1 polymorphism and fasting blood lipid levels.
Meta-analysis of the association between SCARB1 polymorphism and fasting blood lipid levels.
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SCARB1多态性与空腹血脂水平关联的Meta分析
DOI：
10.18632/oncotarget.20867
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发表时间：
2017-10-06
期刊：
影响因子：
--
通讯作者：
Wang LH
中科院分区：
文献类型：
--
作者：
Ye LF;Zheng YR;Zhang QG;Yu JW;Wang LH
研究表明，清道夫受体B 1型（SCARB 1）rs 5888多态性对男性和女性空腹血脂水平的影响不同。因此，进行荟萃分析和统计检验，以确定rs 5888多态性与男性和女性血脂水平之间的关系。本研究选择了12项研究，涉及12，147名受试者。在显性模型中，男性中CT+TT基因型组的甘油三酯水平低于CC组（标准化均值差（SMD）：-0.11; 95%置信区间（CI）：-0.21至0.02; P = 0.016; I2 = 51.5%）。在女性中没有发现统计学差异。不同种族的亚组分析显示，SCARB 1 rs 5888多态性与高密度脂蛋白胆固醇（HDL-C）水平之间存在显著相关性。（SMD：0.15; 95% CI：0.08至0.21; P ≤ 0.001; I2 = 0%）和较低的甘油三酯水平（SMD：-0.16; 95% CI：-0.26至0.04; P = 0.013; I2 = 60.6%）。排除离群值研究时，未观察到异质性证据，也未检测到发表偏倚。这项荟萃分析表明，SCARB 1 rs 5888多态性与非亚洲男性中较高的HDL-C和较低的甘油三酯水平相关。
Studies have shown that the scavenger receptor class B type 1 (SCARB1) rs5888 polymorphism impacts fasting blood lipid levels differently in men and women. A meta-analysis and statistical tests was therefore performed to determine the relationship between the rs5888 polymorphism and lipid levels in men and women. Twelve studies with 12,147 subjects were selected for this study. In a dominant model, the CT+TT genotype group had lower triglyceride levels than the CC group in men (standardized mean difference (SMD): −0.11; 95% confidence interval (CI): −0.21 to −0.02; P = 0.016; I2 = 51.5%). No statistical differences were detected in women. Subgroup analysis of different racial groups revealed significant correlation between the SCARB1 rs5888 polymorphism and higher high-density lipoprotein cholesterol (HDL-C) levels (SMD: 0.15; 95% CI: 0.08 to 0.21; P ≤ 0.001; I2 = 0%) and lower triglyceride levels (SMD: −0.16; 95% CI: −0.26 to −0.04; P = 0.013; I2 = 60.6%) in non-Asian men. No evidence of heterogeneity was observed when eliminating outlier studies, and no publication bias was detected. This meta-analysis suggests the SCARB1 rs5888 polymorphism is associated with higher HDL-C and lower triglyceride levels in non-Asian men.
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影响因子：
24
作者：
Webb TR;Erdmann J;Stirrups KE;Stitziel NO;Masca NG;Jansen H;Kanoni S;Nelson CP;Ferrario PG;König IR;Eicher JD;Johnson AD;Hamby SE;Betsholtz C;Ruusalepp A;Franzén O;Schadt EE;Björkegren JL;Weeke PE;Auer PL;Schick UM;Lu Y;Zhang H;Dube MP;Goel A;Farrall M;Peloso GM;Won HH;Do R;van Iperen E;Kruppa J;Mahajan A;Scott RA;Willenborg C;Braund PS;van Capelleveen JC;Doney AS;Donnelly LA;Asselta R;Merlini PA;Duga S;Marziliano N;Denny JC;Shaffer C;El-Mokhtari NE;Franke A;Heilmann S;Hengstenberg C;Hoffmann P;Holmen OL;Hveem K;Jansson JH;Jöckel KH;Kessler T;Kriebel J;Laugwitz KL;Marouli E;Martinelli N;McCarthy MI;Van Zuydam NR;Meisinger C;Esko T;Mihailov E;Escher SA;Alver M;Moebus S;Morris AD;Virtamo J;Nikpay M;Olivieri O;Provost S;AlQarawi A;Robertson NR;Akinsansya KO;Reilly DF;Vogt TF;Yin W;Asselbergs FW;Kooperberg C;Jackson RD;Stahl E;Müller-Nurasyid M;Strauch K;Varga TV;Waldenberger M;Wellcome Trust Case Control Consortium;Zeng L;Chowdhury R;Salomaa V;Ford I;Jukema JW;Amouyel P;Kontto J;MORGAM Investigators;Nordestgaard BG;Ferrières J;Saleheen D;Sattar N;Surendran P;Wagner A;Young R;Howson JM;Butterworth AS;Danesh J;Ardissino D;Bottinger EP;Erbel R;Franks PW;Girelli D;Hall AS;Hovingh GK;Kastrati A;Lieb W;Meitinger T;Kraus WE;Shah SH;McPherson R;Orho-Melander M;Melander O;Metspalu A;Palmer CN;Peters A;Rader DJ;Reilly MP;Loos RJ;Reiner AP;Roden DM;Tardif JC;Thompson JR;Wareham NJ;Watkins H;Willer CJ;Samani NJ;Schunkert H;Deloukas P;Kathiresan S;Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
通讯作者：
Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators
影响因子：
4.5
作者：
Wu DF;Yin RX;Hu XJ;Aung LH;Cao XL;Miao L;Li Q;Yan TT;Wu JZ;Pan SL
通讯作者：
Pan SL
影响因子：
4.2
作者：
Chang, Eric H.;Rigotti, Attilio;Huerta, Patricio T.
通讯作者：
Huerta, Patricio T.
影响因子：
4
作者：
McCarthy, JJ;Lehner, T;Topol, EJ
通讯作者：
Topol, EJ
影响因子：
4.8
作者：
Ueda, Y;Royer, L;Rubin, EM
通讯作者：
Rubin, EM