Adipose-derived stem cells for treatment of chronic ulcers: current status.
Adipose-derived stem cells for treatment of chronic ulcers: current status.
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DOI：
10.1186/s13287-018-0887-0
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发表时间：
2018-05-15
影响因子：
7.5
通讯作者：
Sorensen JA
中科院分区：
文献类型：
--
作者：
Holm JS;Toyserkani NM;Sorensen JA
慢性溃疡仍然是医疗保健系统中的一项艰巨挑战。虽然治疗选择有限，但干细胞可能是一种新的替代方案。脂肪来源的干细胞(ADSC)与骨髓来源的干细胞相比越来越受欢迎，因为它们更容易获得。为了总结ADSC治疗慢性溃疡的现状，这一系统性综述包括PubMed和EMBASE关于这一主题的所有临床试验，以及ClinicalTrials.gov上注册的所有临床试验。共纳入9项临床试验和14项注册试验。这些研究在研究设计和患者群体方面存在显著差异，研究的总体质量为低到中等。尽管总体研究质量较低，研究之间存在显著差异，但一些结论是一致的：ADSCs是安全的，可以改善慢性溃疡的愈合，并减轻疼痛。尽管这些研究存在缺陷，但这些结果是一致的，它们似乎突显了ADSCs在治疗慢性溃疡方面的疗效。需要更多更高质量的研究来确定ADSCs在治疗慢性腿部溃疡中的确切作用。
Chronic ulcers remain a difficult challenge in healthcare systems. While treatment options are limited, stem cells may be a novel alternative. Adipose-derived stem cells (ADSC) have become increasingly popular compared with bone marrow-derived stem cells as they are far easier to harvest. To summarize the current status of treating chronic ulcers with ADSC, this systematic review includes all clinical trials on the subject from PubMed and EmBase, as well as all registered clinical trials on ClinicalTrials.Gov. A total of nine clinical trials and fourteen registered trials were included. The studies were significantly different in terms of study design and patient population, and the overall quality of the studies was low to moderate. Despite the overall low study quality and the significant differences between the studies, some conclusions were consistent: ADSCs are safe, improve the healing of chronic ulcers, and reduce pain. As these results are consistent despite the shortcomings of the studies, they appear to highlight the efficacy of ADSCs in the treatment of chronic ulcers. Larger numbers of higher quality studies are needed to determine the precise role of ADSCs in treating chronic leg ulcers.
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影响因子：
1.9
作者：
Mohan, A.;Singh, S.
通讯作者：
Singh, S.
DOI：
10.1111/j.1610-0387.2009.07082.x
发表时间：
2009-11-01
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
Serra, Raffaele