Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum.
Comparative Analysis of Active Ingredients and Potential Bioactivities of Essential Oils from Artemisia argyi and A. verlotorum.
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DOI：
10.3390/molecules28093927
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发表时间：
2023-05-06
期刊：
影响因子：
--
通讯作者：
Xu M
中科院分区：
文献类型：
--
作者：
Wang YF;Zheng Y;Feng Y;Chen H;Dai SX;Wang Y;Xu M
艾蒿。香艾是中国艾草的一个变种，在中国中部广泛种植。艾草（A. verlotorum Lamotte）是中国艾草的另一个品种，自古以来就在中国南方地区使用。尽管它们在传统医学中有类似的用途，但人们对它们的有效成分和潜在益处的差异知之甚少。本研究采用色谱-质谱联用（GC-MS）对两个品种精油的化学成分进行了分析。利用中药系统药理学数据库（TCMSP）、SuperPred数据库和R工具等一系列数据库构建中药系统药理学网络。我们的研究结果揭示了两种青蒿的化学成分存在显著差异。然而，我们发现它们具有相似的成分-目标-途径网络，具有不同的生物活性，如神经保护，抗癌和抗炎。此外，我们的蛋白连接网络分析表明，转录因子p65 （RELA）、磷脂酰肌醇3-激酶调控亚基α (PIK3R1)和丝裂原活化蛋白激酶1 （MAPK1）对青蒿的生物活性至关重要。本研究结果为艾草在中国南方作为艾草使用提供了依据。
Artemisia argyi H. Lév. and Vaniot is a variety of Chinese mugwort widely cultured in central China. A. verlotorum Lamotte, another variety of Chinese mugwort, has been used in the southern region of China since ancient times. Despite their similar uses in traditional medicine, little is known about the differences in their active ingredients and potential benefits. Herein, the chemical compositions of the essential oils (EOs) from both varieties were analyzed using chromatography-mass spectrometry (GC-MS). A series of databases, such as the Traditional Chinese Medicine Systems Pharmacology database (TCMSP), SuperPred database and R tool, were applied to build a networking of the EOs. Our results revealed significant differences in the chemical compositions of the two Artemisia EOs. However, we found that they shared similar ingredient–target–pathway networking with diverse bioactivities, such as neuroprotective, anti-cancer and anti-inflammatory. Furthermore, our protein connection networking analysis showed that transcription factor p65 (RELA), phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) and mitogen-activated protein kinase 1 (MAPK1) are crucial for the biological activity of Artemisia EOs. Our findings provided evidence for the use of A. verlotorum as Chinese mugwort in southern China.
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