Recovery of carotid body O2 sensitivity following chronic postnatal hyperoxia in rats.
Recovery of carotid body O2 sensitivity following chronic postnatal hyperoxia in rats.
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DOI：
10.1016/j.resp.2011.03.012
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发表时间：
2011-06-30
影响因子：
2.3
通讯作者：
Donnelly, David F.
中科院分区：
文献类型：
--
作者：
Bavis, Ryan W.;Kim, Insook;Pradhan, Nelish;Nawreen, Nawshaba;Dmitrieff, Elizabeth F.;Carroll, John L.;Donnelly, David F.
慢性出生后高氧减弱大鼠的低氧反应（HVR），这种作用在恢复正常氧后持续数月。为了确定是否降低颈动脉体O2的敏感性有助于这种持久的损害，单单位化学传入神经和球细胞钙反应缺氧记录从大鼠饲养在60%O2通过7天的年龄（P7），然后返回到常氧。单单位神经反应在P4时减弱，并在P7时保持较低水平。恢复常氧后，缺氧反应在3 d内部分恢复，7-8 d内完全恢复（即，第14 -15页）。血管球细胞钙反应以类似的时间过程恢复。高氧改变了颈动脉体中O2敏感性K+通道ASK-1、ASK-3和BKCa的mRNA，但只有ASK-1 mRNA抑制了化学敏感性的变化（即，P7下调，P14部分恢复）。总的来说，这些数据不支持的作用，O2敏感性降低的个别化学感受器细胞在长期持久的减少HVR后发展高氧。
Chronic postnatal hyperoxia blunts the hypoxic ventilatory response (HVR) in rats, an effect that persists for months after return to normoxia. To determine whether decreased carotid body O2 sensitivity contributes to this lasting impairment, single-unit chemoafferent nerve and glomus cell calcium responses to hypoxia were recorded from rats reared in 60% O2 through 7 d of age (P7) and then returned to normoxia. Single-unit nerve responses were attenuated by P4 and remained low through P7. After return to normoxia, hypoxic responses were partially recovered within 3 d and fully recovered within 7–8 d (i.e., at P14-15). Glomus cell calcium responses recovered with a similar time course. Hyperoxia altered carotid body mRNA for O2-sensitive K+ channels TASK-1, TASK-3, and BKCa, but only TASK-1 mRNA paralleled changes in chemosensitivity (i.e., downregulation by P7, partial recovery by P14). Collectively, these data do not support a role for reduced O2 sensitivity of individual chemoreceptor cells in long-lasting reduction of the HVR after developmental hyperoxia.
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影响因子：
2.3
作者：
Dmitrieff, Elizabeth F.;Wilson, Julia T.;Dunmire, Kyle B.;Bavis, Ryan W.
通讯作者：
Bavis, Ryan W.
DOI：
10.1111/j.1749-6632.2009.05037.x
发表时间：
2009-01-01
期刊：
HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY
影响因子：
--
作者：
Gonzalez, Constancio;Vaquero, Luis M.;Teresa Perez-Garcia, M.
通讯作者：
Teresa Perez-Garcia, M.
影响因子：
3.3
作者：
Bavis, Ryan W.;Young, Kristen M.;Rampersad, Donna A.
通讯作者：
Rampersad, Donna A.
影响因子：
3.3
作者：
Donnelly, DF;Kim, I;Carroll, JL
通讯作者：
Carroll, JL
DOI：
10.1016/s0034-5687(97)00091-1
发表时间：
1997-11-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
Ling, L;Olson, EB;Mitchell, GS
通讯作者：
Mitchell, GS