Biopolymer-connected liposome networks as injectable biomaterials capable of sustained local drug delivery.
Biopolymer-connected liposome networks as injectable biomaterials capable of sustained local drug delivery.
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DOI：
10.1021/bm301143d
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发表时间：
2012-10-08
影响因子：
6.2
通讯作者：
Blumenthal, Robert
中科院分区：
文献类型：
--
作者：
Lee, Jae-Ho;Oh, Hyuntaek;Baxa, Ulrich;Raghavan, Srinivasa R.;Blumenthal, Robert
含有疏水侧链的生物聚合物，如疏水改性壳聚糖(HMC)，可以通过疏水相互作用将脂质体连接成凝胶网络。在这篇文章中，我们展示了这种脂质体凝胶在某些药物输送应用中具有吸引人的性能组合。它们的剪切稀释性使这些凝胶可以在特定部位注射，而它们静止时的凝胶性质确保了材料将保持在该部位的局部。此外，药物可以被包裹在脂质体的内部，并在局部位置延长时间。两种转运阻力的存在--来自脂质体双层和凝胶网络--被证明是导致持续释放的原因；反过来，脂质体的破坏既削弱了凝胶，又导致了更快的释放。我们监测了阳离子抗癌药物阿霉素(Dox)从脂质体凝胶中的释放动力学。Dox从这些凝胶中的持续释放和伴随的细胞毒性效应可以观察到一周以上。
Biopolymers bearing hydrophobic side-chains, such as hydrophobically modified chitosan (hmC), can connect liposomes into a gel network via hydrophobic interactions. In this paper, we show that such liposome gels possess an attractive combination of properties for certain drug delivery applications. Their shear-thinning property allows these gels to be injected at a particular site, while their gel-like nature at rest ensures that the material will remain localized at that site. Moreover, drugs can be encapsulated in the interior of the liposomes and delivered at the local site for an extended period of time. The presence of two transport resistances – from the liposomal bilayer and the gel network – is shown to be responsible for the sustained release; in turn, disruption of the liposomes both weakens the gel and causes a faster release. We have monitored release kinetics from liposome gels of a cationic anti-cancer drug doxorubicin (Dox) encapsulated in liposomes. Sustained release of Dox from these gels and the concomitant cytotoxic effect could be observed for over a week.
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