The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells.
复制标题
DOI：
10.1016/j.celrep.2017.10.114
复制
发表时间：
2017-11-21
期刊：
影响因子：
8.8
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Ye J;Qiu J;Bostick JW;Ueda A;Schjerven H;Li S;Jobin C;Chen ZE;Zhou L
局部环境可能会影响组织驻留T调节细胞(Tregs)的发育和功能，Tregs是控制炎症的关键。虽然芳香烃受体(Ahr)是一种环境感受器，但它在Treg细胞发育和/或功能中的作用仍然不清楚。在这里，我们建立了小鼠基因模型，以消除或激活Tregs中特异的AhR表达。我们发现，外周诱导的Treg(PTregs)在肠道中可以更丰富地表达AhR，而且它的表达不依赖于微生物区系。AHR对Treg肠道归巢和功能非常重要。AHR可抑制Treg产生的促炎细胞因子，但对Treg的稳定性是必不可少的。此外，在结肠炎的T细胞转移模型中，与缺乏AhR表达的Tregs相比，表达Ahr的Tregs具有更强的体内抑制活性。我们的数据表明，Treg中的Ahr信号可能对肠道免疫动态平衡很重要。叶等人发现AhR在肠道中由外周来源的Treg(PTreg)最丰富地表达。AHR的表达和激活对Treg肠道归巢和抑制肠道炎症的功能非常重要。
Local environment may impact the development and function of tissue-resident T regulatory cells (Tregs) that are crucial for controlling inflammation. Although the aryl hydrocarbon receptor (Ahr), an environmental sensor, is expressed by Tregs, its role in Treg cell development and/or function remains elusive. Here, we generated mouse genetic models to ablate or activate Ahr expression specifically in Tregs. We showed that Ahr was expressed more abundantly by peripherally induced Treg (pTregs) in the gut, and its expression was independent of microbiota. Ahr was important for Treg gut homing and function. Ahr inhibited pro-inflammatory cytokines produced by Tregs but was dispensable for Treg stability. Furthermore, Ahr-expressing Tregs had enhanced in vivo suppressive activity compared to Tregs lacking Ahr expression in a T cell transfer model of colitis. Our data suggest that Ahr signaling in Tregs may be important for gut immune homeostasis. Ye et al. fnd that Ahr is most abundantly expressed by peripherally derived Tregs (pTreg) in the gut. Ahr expression and activation are important for Treg gut homing and function to suppress intestinal inflammation.
登录
查看更多内容
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
32.4
作者：
Basu R;O'Quinn DB;Silberger DJ;Schoeb TR;Fouser L;Ouyang W;Hatton RD;Weaver CT
通讯作者：
Weaver CT
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K