Cardiovascular and All-Cause Mortality Over a 23-Year Period Among Chinese With Newly Diagnosed Diabetes in the Da Qing IGT and Diabetes Study.
Cardiovascular and All-Cause Mortality Over a 23-Year Period Among Chinese With Newly Diagnosed Diabetes in the Da Qing IGT and Diabetes Study.
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DOI：
10.2337/dc14-2498
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发表时间：
2015-07
期刊：
影响因子：
16.2
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
An Y;Zhang P;Wang J;Gong Q;Gregg EW;Yang W;Li H;Zhang B;Shuai Y;Chen Y;Engelgau MM;Cheng Y;Hu Y;Bennett PH;Li G
尽管糖尿病在中国中的患病率越来越高，但糖尿病在多大程度上导致心血管疾病和全因死亡尚不清楚。我们比较了1986年在中国大庆筛查110,660例25~74岁成人糖尿病中新诊断的糖尿病患者630例和糖耐量正常的519例的死亡率和死因。在23年的随访中，338名(56.5%)患有NDD的患者和100名(20.3%)患有NGT的患者死亡。心血管疾病是糖尿病患者的主要死亡原因(男性47.5%，女性49.7%)，其中近一半是由于中风(男性52.3%，女性42.3%)。新城疫患者的年龄标化死亡率是非糖尿病患者的三倍，男性(P<；0.0001)和女性(P<；0.0001)的全死因死亡率分别为36.9%(95%CI31.5-42.3%)和13.3%(10.2-16.5%)和27.1%(22.9%-31.4)和9.2%(7.8%-10.6)。患有新城疫的男性和女性的心血管死亡发生率(17.5[13.8-21.2]比13.5[10.5-16.5])没有显著差异。NDD组的肾脏疾病和感染的死亡率也显著较高。糖尿病与中国成年人死亡风险的显著增加有关，特别是由心血管疾病引起的死亡风险，其中近一半是由于中风。
Despite its growing prevalence in China, the extent to which diabetes leads to excess cardiovascular disease (CVD) mortality and all-cause mortality is unclear. We compared death rates and causes of death among 630 people with newly diagnosed diabetes (NDD) and 519 with normal glucose tolerance (NGT) who, in 1986, were identified as a result of screening 110,660 adults aged 25–74 years for diabetes in Da Qing, China. During 23 years of follow-up, 338 (56.5%) participants with NDD and 100 (20.3%) with NGT died. CVD was the predominant cause of death in those with diabetes (47.5% in men and 49.7% in women), almost half of which was due to stroke (52.3% in men and 42.3% in women). The age-standardized incidence of all-cause death was three times as high in those with NDD as in those with NGT with incidences (per 1,000 person-years) of 36.9 (95% CI 31.5–42.3) vs. 13.3 (10.2–16.5) in men (P < 0.0001) and 27.1 (22.9–31.4) vs. 9.2 (7.8–10.6) in women (P < 0.0001). The incidence of CVD deaths in men and women with NDD (17.5 [13.8–21.2] vs. 13.5 [10.5–16.5]) did not differ significantly. Significantly higher death rates attributable to renal disease and infection were also found in the NDD group. Diabetes is associated with a substantially increased risk of death in Chinese adults, especially from CVD, almost half of which is due to stroke.
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影响因子：
5.1
作者：
SASAKI, A;HORIUCHI, N;UEHARA, M
通讯作者：
UEHARA, M
影响因子：
105.7
作者：
Huxley, R;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
16.2
作者：
PAN, XR;HU, YH;HOWARD, BV
通讯作者：
HOWARD, BV
影响因子：
16.2
作者：
Pan, XR;Li, GW;Howard, BV
通讯作者：
Howard, BV
影响因子：
8.2
作者：
de Vegt, F;Dekker, JM;Heine, RJ
通讯作者：
Heine, RJ