A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder
A new locus regulating MICALL2 expression was identified for association with executive inhibition in children with attention deficit hyperactivity disorder
复制标题
确定了一个新的调节 MICALL2 表达的位点，该位点与注意力缺陷多动障碍儿童的执行抑制相关
DOI：
10.1038/mp.2017.74
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发表时间：
2018-04
影响因子：
11
通讯作者：
Wang
中科院分区：
文献类型：
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作者：
Yang L.;Lu Q.;Wu Z.;Sun X.;Cao Q.;Qian Y.;Wang Y.;Lu L.;Yang L.;Lu Q.;Wu Z.;Sun X.;Cao Q.;Qian Y.;Wang Y.;Lu L.;Chang S.;Wang J.;Chang S.;Wang J.;Zhang Y.;Jia T.;Xu B.;Schumann G.;Jia T.;Xu B.;Schumann G.;Duan Q.;Li Y.;Li Y.;Li Y.;Liu D.;Liu D;Wang J;Wang
行政抑制受损是注意力缺陷多动障碍（ADHD）的核心赤字，这是一种常见的儿童期性精神病，具有较高的遗传力。在这项研究中，我们对EXE进行了两阶段的全基因组关联研究
Impaired executive inhibition is a core deficit of attention deficit hyperactivity disorder (ADHD), which is a common childhood-onset psychiatric disorder with high heritability. In this study, we performed a two-stage genome-wide association study of executive inhibition in ADHD in Han Chinese. We used the Stroop color-word interference test to evaluate executive inhibition. After quality control, 780 samples with phenotype and covariate data were included in the discovery stage, whereas 922 samples were included in the replication stage. We identified one new significant locus at 7p22. 3 for the Stroop word interference time (rs11514810, P= 3.42 E− 09 for discovery, P= 0.01176 for replication and combined P= 5.249 E− 09). Regulatory feature analysis and expression quantitative trait loci (eQTL) data showed that this locus contributes to MICALL2 expression in the human brain. Most genes in the network interacting with MICALL2 were associated with psychiatric disorders. Furthermore, hyperactive-impulsive-like behavior was induced by reducing the expression of the zebrafish gene that is homologous to MICALL2, which could be rescued by tomoxetine (atomoxetine), a clinical medication for ADHD. Our results suggested that MICALL2 is a new susceptibility gene for executive inhibition deficiency related to hyperactive-impulsive behavior in ADHD, further emphasizing the possible role of neurodevelopmental genes in the pathogenic mechanism of ADHD.
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DOI：
10.3109/15622975.2016.1173724
发表时间：
2017-06
期刊：
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
影响因子：
--
作者：
Richards JS;Arias Vásquez A;van Rooij D;van der Meer D;Franke B;Hoekstra PJ;Heslenfeld DJ;Oosterlaan J;Faraone SV;Hartman CA;Buitelaar JK
通讯作者：
Buitelaar JK
来自1,092个人基因组的遗传变异的综合图。
影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1016/j.jaac.2010.06.008
发表时间：
2010-09
影响因子：
13.3
作者：
Neale BM;Medland SE;Ripke S;Asherson P;Franke B;Lesch KP;Faraone SV;Nguyen TT;Schäfer H;Holmans P;Daly M;Steinhausen HC;Freitag C;Reif A;Renner TJ;Romanos M;Romanos J;Walitza S;Warnke A;Meyer J;Palmason H;Buitelaar J;Vasquez AA;Lambregts-Rommelse N;Gill M;Anney RJ;Langely K;O'Donovan M;Williams N;Owen M;Thapar A;Kent L;Sergeant J;Roeyers H;Mick E;Biederman J;Doyle A;Smalley S;Loo S;Hakonarson H;Elia J;Todorov A;Miranda A;Mulas F;Ebstein RP;Rothenberger A;Banaschewski T;Oades RD;Sonuga-Barke E;McGough J;Nisenbaum L;Middleton F;Hu X;Nelson S;Psychiatric GWAS Consortium: ADHD Subgroup
通讯作者：
Psychiatric GWAS Consortium: ADHD Subgroup
DOI：
10.1002/ajmg.b.31246
发表时间：
2011-12-01
影响因子：
2.8
作者：
Hinney, Anke;Scherag, Andre;Hebebrand, Johannes
通讯作者：
Hebebrand, Johannes
影响因子：
--
作者：
N. Nishimura;Takuya Sasaki
通讯作者：
N. Nishimura;Takuya Sasaki