Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model.
Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model.
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DOI：
10.3390/molecules19033247
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发表时间：
2014-03-17
期刊：
影响因子：
--
通讯作者：
Shido O
中科院分区：
文献类型：
--
作者：
Katakura M;Hashimoto M;Inoue T;Al Mamun A;Tanabe Y;Iwamoto R;Arita M;Tsuchikura S;Shido O
ω-3多不饱和脂肪酸（ω-3 PUFA）、二十二碳六烯酸（DHA）和/或二十碳五烯酸（EPA）通过抑制炎症来预防糖尿病肾病。本研究的目的是评估在代谢综合征动物模型SHR.Cg-Leprcp/NDmcr（SHRcp）大鼠中给予高度纯化的DHA和EPA或仅给予EPA对肾功能和肾类二十烷酸和类二十二烷酸水平的影响。雄性SHRcp大鼠分为3组。对照（5%阿拉伯胶）、TAK-085（300 mg/kg/天，含467 mg/g EPA和365 mg/g DHA）或EPA（300 mg/kg/天）经口给药20周。TAK-085给药组的尿白蛋白/肌酐比值显著低于其他组。TAK-085给药组的肾小球硬化评分显著低于其他组。尽管总肾脏脂肪酸中的DHA水平升高，但3组间非酯化DHA水平无显著差异，而TAK-085给药组中的保护素D1、消退素D1和消退素D2水平显著升高。结果表明，在SHRcp大鼠中使用DHA和EPA的组合疗法通过降低甘油三酯水平和增加ω-3 PUFA脂质介质来改善或预防与代谢综合征相关的肾衰竭。
The omega-3 polyunsaturated fatty acids (ω-3 PUFAs) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA) protect against diabetic nephropathy by inhibiting inflammation. The aim of this study was to assess the effects of highly purified DHA and EPA or EPA only administration on renal function and renal eicosanoid and docosanoid levels in an animal model of metabolic syndrome, SHR.Cg-Leprcp/NDmcr (SHRcp) rats. Male SHRcp rats were divided into 3 groups. Control (5% arabic gum), TAK-085 (300 mg/kg/day, containing 467 mg/g EPA and 365 mg/g DHA), or EPA (300 mg/kg/day) was orally administered for 20 weeks. The urinary albumin to creatinine ratio in the TAK-085-administered group was significantly lower than that in other groups. The glomerular sclerosis score in the TAK-085-administered group was significantly lower than that in the other groups. Although DHA levels were increased in total kidney fatty acids, the levels of nonesterified DHA were not significantly different among the 3 groups, whereas the levels of protectin D1, resolvin D1, and resolvin D2 were significantly increased in the TAK-085-administered group. The results show that the use of combination therapy with DHA and EPA in SHRcp rats improved or prevented renal failure associate with metabolic syndrome with decreasing triglyceride levels and increasing ω-3 PUFA lipid mediators.
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影响因子：
19.6
作者：
Andrade, L;Campos, SB;Seguro, AC
通讯作者：
Seguro, AC
DOI：
10.1074/jbc.m112.340612
发表时间：
2012-03-23
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Isobe Y;Arita M;Matsueda S;Iwamoto R;Fujihara T;Nakanishi H;Taguchi R;Masuda K;Sasaki K;Urabe D;Inoue M;Arai H
通讯作者：
Arai H
影响因子：
3.2
作者：
Bobulescu IA
通讯作者：
Bobulescu IA
影响因子：
2.9
作者：
Katakura M;Hashimoto M;Tanabe Y;Shido O
通讯作者：
Shido O
影响因子：
4.4
作者：
Hassan, Iram R.;Gronert, Karsten
通讯作者：
Gronert, Karsten