Percutaneous implants with porous titanium dermal barriers: an in vivo evaluation of infection risk.
Percutaneous implants with porous titanium dermal barriers: an in vivo evaluation of infection risk.
复制标题
具有多孔钛皮肤屏障的经皮植入物：感染风险的体内评估。
DOI：
10.1016/j.medengphy.2010.11.007
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发表时间：
2011-05
影响因子：
2.2
通讯作者：
Bachus KN
中科院分区：
文献类型：
--
作者：
Isackson D;McGill LD;Bachus KN
Osseointegrated percutaneous implants are a promising prosthetic alternative for a subset of amputees. However, as with all percutaneous implants, they have an increased risk of infection since they breach the skin barrier. Theoretically, host tissues could attach to the metal implant creating a barrier to infection. When compared with smooth surfaces, it is hypothesized that porous surfaces improve the attachment of the host tissues to the implant, and decrease the infection risk. In this study, 4 titanium implants, manufactured with a percutaneous post and a subcutaneous disk, were placed subcutaneously on the dorsum of eight New Zealand White rabbits. Beginning at four weeks post-op, the implants were inoculated weekly with 108 CFU Staphylococcus aureus until signs of clinical infection presented. While we were unable to detect a difference in the incidence of infection of the porous metal implants, smooth surface (no porous coating) percutaneous and subcutaneous components had a 7-fold increased risk of infection compared to the implants with a porous coating on one or both components. The porous coated implants displayed excellent tissue ingrowth into the porous structures; whereas, the smooth implants were surrounded with a thick, organized fibrotic capsule that was separated from the implant surface. This study suggests that porous coated metal percutaneous implants are at a significantly lower risk of infection when compared to smooth metal implants. The smooth surface percutaneous implants were inadequate in allowing a long-term seal to develop with the soft tissue, thus increasing vulnerability to the migration of infecting microorganisms.
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影响因子：
4.9
作者：
Chou, Teri G. Rosenbaum;Petti, Cathy A.;Bloebaum, Roy D.
通讯作者：
Bloebaum, Roy D.
DOI：
10.1002/jbm.820180405
发表时间：
1984-01-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
GROSSESIESTRUP, C;AFFELD, K
通讯作者：
AFFELD, K
影响因子：
--
作者：
EMMANUAL, J;HORNBECK, C;BLOEBAUM, RD
通讯作者：
BLOEBAUM, RD
影响因子：
3.8
作者：
GANGJEE, T;COLAIZZO, R;VONRECUM, AF
通讯作者：
VONRECUM, AF
影响因子：
1.5
作者：
Jacobs, R;Brånemark, R;Brånemark, PI
通讯作者：
Brånemark, PI