Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation.
Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation.
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DOI：
10.1016/j.bbi.2020.09.003
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Gilman SE
中科院分区：
文献类型：
--
作者：
Yu J;Ghassabian A;Chen Z;Goldstein RB;Hornig M;Buka SL;Goldstein JM;Gilman SE
怀孕期间的母亲免疫活动与后代患精神疾病的风险有关，但人们对其对儿童情绪和行为发育的影响知之甚少。这项研究检测了产前血清中五种细胞因子的浓度是否与社会经济地位(SES)和后代自我调节能力的种族差异有关。参与者包括合作围产期项目(CPP)的1,628名妇女。在儿童4岁时，CPP心理学家对7个概念上与自我调节有关的行为项目进行了评定。检测血清IL-1β、IL-6、IL-8、肿瘤坏死因子-α、IL-10水平。协变量包括儿童性别和母亲的年龄、精神障碍和怀孕期间的医疗状况。在儿童自我调节方面存在显著的社会地位差异，社会地位越高的儿童在自我调节上得分更高(β=.18，95%CI[.11，.25])，但没有种族差异。母亲血清中IL-8浓度与儿童较高的自我调节能力相关，β=0.09，95%CI[0.02，0.16]。在中介分析中，母亲IL-8的变化有助于家庭自尊和儿童自我调节之间的联系(β=0.02，95%CI[.003，.030])，解释了约十分之一的自律差异。这项研究表明，怀孕是一个早期敏感期，母亲的免疫活动是儿童发育的一个重要背景。
Maternal immune activity during pregnancy has been associated with risk for psychiatric disorders in offspring, but less is known about its implications for children’s emotional and behavioral development. This study examined whether concentrations of five cytokines assayed from prenatal serum were associated with socioeconomic status (SES) and racial disparities in their offspring’s self-regulation abilities. Participants included 1,628 women in the Collaborative Perinatal Project (CPP). Seven behavioral items conceptually related to self-regulation were rated by CPP psychologists when children were 4 years old. Concentrations of interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and IL-10 were assessed. Covariates included child sex and mother’s age, psychiatric disorders, and medical conditions during pregnancy. There were significant SES differences in child self-regulation, with higher SES children scoring higher on self-regulation (β = .18, 95% CI [.11, .25]), but no racial differences. The concentration of IL-8 in maternal serum was associated with higher child self-regulation, β = .09, 95% CI [.02, .16]. In mediation analyses, variation in maternal IL-8 contributed to the association between family SES and child self-regulation (β = .02, 95% CI [.003, .030]), explaining about one-tenth of the SES disparities. This study suggests pregnancy as an early sensitive period and maternal immune activity as an important context for child development.
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影响因子：
6.9
作者：
Goldstein, J. M.;Cherkerzian, S.;Buka, S. L.
通讯作者：
Buka, S. L.
影响因子：
4.2
作者：
Kubzansky, LD;Martin, LT;Buka, SL
通讯作者：
Buka, SL
影响因子：
15.1
作者：
Buka, SL;Tsuang, MT;Yolken, RH
通讯作者：
Yolken, RH
DOI：
10.1073/pnas.1617698114
发表时间：
2017-06-27
影响因子：
11.1
作者：
Gilman, Stephen E.;Hornig, Mady;Goldstein, Jill M.
通讯作者：
Goldstein, Jill M.
DOI：
10.1016/j.bbi.2018.06.011
发表时间：
2018-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Gustafsson HC;Sullivan EL;Nousen EK;Sullivan CA;Huang E;Rincon M;Nigg JT;Loftis JM
通讯作者：
Loftis JM