Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study.
Longitudinal Changes in Macular Optical Coherence Tomography Angiography Metrics in Primary Open-Angle Glaucoma With High Myopia: A Prospective Study.
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DOI：
10.1167/iovs.62.1.30
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发表时间：
2021-01-04
影响因子：
4.4
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Lin F;Li F;Gao K;He W;Zeng J;Chen Y;Chen M;Cheng W;Song Y;Peng Y;Jin L;Lin TPH;Wang Y;Tham CC;Cheung CY;Zhang X
通过光学相干断层扫描血管造影（OCTA）指标，描述伴有和不伴有高度近视的原发性开角型青光眼（POAG）眼黄斑微血管的纵向变化。总共有63只和61只POAG患眼（伴有和不伴有高度近视）在眼科中心至少4次随访中接受了扫频源OCTA成像，扫描方案为3 × 3 mm，以中央凹为中心。测量视网膜中央凹无血管区（FAZ）面积、FAZ圆度、浅表（SCP）和深毛细血管丛（DCP）血管密度（VD）。使用线性混合效应模型估计两组POAG眼黄斑OCTA指标随时间的变化率。POAG伴高度近视眼平均随访时间27.72 ± 8.57个月，平均随访8.5（8 ~ 13）次; POAG不伴高度近视眼平均随访时间30.95 ± 10.19个月，平均随访10（8 ~ 13）次。有高度近视的POAG眼中DCP的VD下降速度明显快于无高度近视的POAG眼（−5.14%/年vs. −3.71%/年，P = 0.008）。此外，DCP组较低的基线VD与POAG伴高度近视眼的较快VD降低显著相关（P < 0.001）。相反，两组SCP、FAZ区域的VD减少率以及SCP和DCP的FAZ圆形度相似（所有P> 0.05）。随着时间的推移，高度近视的POAG眼DCP的VD下降更快。当基线VD较低时，DCP中的密度降低得更快。
To characterize longitudinal changes in macular microvasculature as quantified from optical coherence tomography angiography (OCTA) metrics in primary open-angle glaucoma (POAG) eyes with and without high myopia. In total, 63 and 61 POAG eyes with and without high myopia, respectively, underwent swept-source OCTA imaging in at least four follow-up visits at an ophthalmic center, with a scanning protocol of 3- × 3-mm centered at the fovea. The foveal avascular zone (FAZ) area, FAZ circularity, and vessel density (VD) in both the superficial (SCP) and deep capillary plexuses (DCP) were measured. The rate of change in macular OCTA metrics over time was estimated using linear mixed-effects models in both groups of POAG eyes. The mean follow-up time and number of visits were 27.72 ± 8.57 months and 8.5 (8 to 13) times, and 30.95 ± 10.19 months and 10 (8‒13) times in POAG eyes with and without high myopia, respectively. VD in the DCP reduced significantly more quickly in POAG eyes with high myopia than in those without high myopia (−5.14%/year vs. −3.71%/year, P = 0.008). Moreover, lower baseline VD in the DCP was significantly associated with faster VD reduction in POAG with high myopia eyes (P < 0.001). Conversely, the VD reduction rate in the SCP, FAZ area, and FAZ circularity in both the SCP and DCP were similar in both groups (all Ps > 0.05). VD in DCP reduced significantly more quickly in POAG eyes with high myopia over time. Density in the DCP reduced more quickly when baseline VD was low.
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影响因子：
17.8
作者：
Kur, Joanna;Newman, Eric A.;Chan-Ling, Tailoi
通讯作者：
Chan-Ling, Tailoi
影响因子：
17.8
作者：
Hood DC;Raza AS;de Moraes CG;Liebmann JM;Ritch R
通讯作者：
Ritch R
影响因子：
4.2
作者：
Feke, Gilbert T.;Bex, Peter J.;Pasquale, Louis R.
通讯作者：
Pasquale, Louis R.
影响因子：
4.4
作者：
Man, Ryan Eyn Kidd;Lamoureux, Ecosse L.;Luu, Chi D.
通讯作者：
Luu, Chi D.
影响因子：
13.7
作者：
Hou, Huiyuan;Moghimi, Sasan;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.