Similarities and differences between parietal and frontal patients in autobiographical and constructed experience tasks.
Similarities and differences between parietal and frontal patients in autobiographical and constructed experience tasks.
复制标题
顶叶和额叶患者在自传体和构建经验任务中的异同。
DOI：
10.1016/j.neuropsychologia.2010.01.004
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发表时间：
2010-04
期刊：
影响因子：
2.6
通讯作者：
Olson IR
中科院分区：
文献类型：
--
作者：
Berryhill ME;Picasso L;Arnold R;Drowos D;Olson IR
最近的研究结果表明，构建的经验，想象未来事件的能力，激活了与回忆过去事件相同的皮层网络。例如，一个关键区域海马体的损伤会削弱患者记忆过去和想象新经历的能力。在这里，我们调查了其他两个区域的损伤，后顶叶皮层和前额叶皮层，是否也会损害这种能力。测试双侧后顶叶损伤或单侧前额叶损伤的患者描述想象未来事件的能力。只有顶叶患者在自由描述自传体记忆受损，但两个病人组都受损时，精心构建的经验。这种分离表明，顶叶和前额叶结构的差异参与建构的经验。目前的任务可能会强加过于广泛的认知需求，使其无法指定任何患者组中的认知缺陷。这些发现为顶叶皮层在记忆中的机械作用提供了额外的限制。
Recent findings suggest that constructed experience, the ability to envision future events, activates the same cortical network as recollection of past events. For example, damage to one key area, the hippocampus, impairs patients' ability to remember the past and to imagine novel experiences. Here, we investigated whether damage to two other areas, posterior parietal cortex and prefrontal cortex, also impairs this ability. Patients with bilateral posterior parietal lesions or unilateral prefrontal lesions were tested in their ability to describe imaginary future events. Only parietal patients were impaired at freely describing autobiographical memories, but both patient groups were impaired when elaborating constructed experiences. This dissociation suggests that parietal and prefrontal structures are differentially involved in constructed experience. Current tasks may impose overly broad cognitive demands making it impossible to specify the deficient cognitive component in any patient group. These findings provide additional constraints regarding the mechanistic role of the parietal cortex in memory.
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DOI：
10.1523/jneurosci.4549-07.2007
发表时间：
2007-12-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hassabis D;Kumaran D;Maguire EA
通讯作者：
Maguire EA
影响因子：
2.6
作者：
Addis, Donna Rose;Wong, Alana T.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
3.2
作者：
Fellows, Lesley K.;Stark, Marianna;Chatterjee, Anjan
通讯作者：
Chatterjee, Anjan
影响因子：
2.6
作者：
Addis, Donna Rose;Pan, Ling;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
DOI：
10.1073/pnas.0610561104
发表时间：
2007-01-30
影响因子：
11.1
作者：
Hassabis, Dernis;Kumaran, Dharshan;Maguire, Eleanor A.
通讯作者：
Maguire, Eleanor A.