Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging.
Cascade of neural events leading from error commission to subsequent awareness revealed using EEG source imaging.
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DOI：
10.1371/journal.pone.0019578
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发表时间：
2011-05-05
期刊：
影响因子：
3.7
通讯作者：
Pourtois G
中科院分区：
文献类型：
--
作者：
Dhar M;Wiersema JR;Pourtois G
本研究的目的是阐明三个重要的行动监测大脑区域（即扣带皮层，颞叶，眶额皮层）在有意识地检测反应错误的各自的贡献。为此，14名健康的成年人进行了一项快速的Go/Nogo任务，包括不同难度的Nogo试验，旨在引起意识和意识不到的错误。参与者在按下目标键后按下第二个键，以指示错误意识。同时记录反应手的肌电图和高密度头皮脑电图。在EMG锁定的总平均值中，意识错误明显地引发了反映错误检测的错误相关负性（ERN），以及反映有意识错误意识的错误相关正性（Pe）。然而，在无意识的错误或命中后没有记录Pe。这些结果与以前的研究表明，错误意识与产生的Pe。源定位结果证实，后扣带运动区是ERN的主要发生器。然而，逆解的结果也指向参与的左后颞叶在时间间隔的Pe，因此错误的意识。此外，连续到这个岛的活动，右眶额皮质（OFC）被激活，在意识到和不知道的错误，但不响应于命中，这与该地区的错误的价值评估的含义一致。这些结果揭示了错误发生后这三个不重叠的大脑区域的精确激活序列，使意识和无意识错误之间的渐进区分成为时间流逝的函数，这要归功于首先参与内感受或本体感受过程（左OFC），随后导致检测到优势反应模式（右OFC）的突破。
The goal of the present study was to shed light on the respective contributions of three important action monitoring brain regions (i.e. cingulate cortex, insula, and orbitofrontal cortex) during the conscious detection of response errors. To this end, fourteen healthy adults performed a speeded Go/Nogo task comprising Nogo trials of varying levels of difficulty, designed to elicit aware and unaware errors. Error awareness was indicated by participants with a second key press after the target key press. Meanwhile, electromyogram (EMG) from the response hand was recorded in addition to high-density scalp electroencephalogram (EEG). In the EMG-locked grand averages, aware errors clearly elicited an error-related negativity (ERN) reflecting error detection, and a later error positivity (Pe) reflecting conscious error awareness. However, no Pe was recorded after unaware errors or hits. These results are in line with previous studies suggesting that error awareness is associated with generation of the Pe. Source localisation results confirmed that the posterior cingulate motor area was the main generator of the ERN. However, inverse solution results also point to the involvement of the left posterior insula during the time interval of the Pe, and hence error awareness. Moreover, consecutive to this insular activity, the right orbitofrontal cortex (OFC) was activated in response to aware and unaware errors but not in response to hits, consistent with the implication of this area in the evaluation of the value of an error. These results reveal a precise sequence of activations in these three non-overlapping brain regions following error commission, enabling a progressive differentiation between aware and unaware errors as a function of time elapsed, thanks to the involvement first of interoceptive or proprioceptive processes (left insula), later leading to the detection of a breach in the prepotent response mode (right OFC).
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影响因子：
3.7
作者：
Bechara, A;Tranel, D;Damasio, AR
通讯作者：
Damasio, AR
影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
DOI：
10.1098/rstb.1996.0125
发表时间：
1996-10-29
影响因子：
6.3
作者：
Damasio, AR
通讯作者：
Damasio, AR
影响因子：
2.5
作者：
Critchley, HD
通讯作者：
Critchley, HD
DOI：
10.1016/j.cogbrainres.2004.02.013
发表时间：
2004-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Herrmann, MJ;Römmler, J;Fallgatter, AJ
通讯作者：
Fallgatter, AJ