Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI.
Characterization of regional heterogeneity in cerebrovascular reactivity dynamics using novel hypocapnia task and BOLD fMRI.
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DOI：
10.1016/j.neuroimage.2009.05.026
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发表时间：
2009-10-15
期刊：
影响因子：
5.7
通讯作者：
Duyn, Jeff H.
中科院分区：
文献类型：
--
作者：
Bright, Molly G.;Bulte, Daniel P.;Jezzard, Peter;Duyn, Jeff H.
我们提供了一种新的方法来表征的幅度和动态的血管反应的变化，动脉气体紧张度使用无创性血氧水平依赖性功能磁共振成像（BOLD fMRI）和范式适合于临床设置。一种新的呼吸任务，“提示深呼吸”（CDB），由两个连续的提示呼吸循环组成，已被开发用于引起短暂的低碳酸血症，并因此导致强烈的、短暂的BOLD信号减少。从CDB低碳酸血症范例和传统的屏气高碳酸血症范例的数据进行了分析，在体素的基础上映射的幅度和时间参数的区域异质性。这些任务引起了相当的绝对BOLD百分比信号变化（灰质中约0.5-3.0%），并且两个数据集都表明响应时间具有一致的区域异质性：基底神经节的部分区域，特别是壳核，以及内侧皮质的双侧区域达到最大信号变化比剩余皮质灰质体素早几秒。在10名健康受试者的组图中存在这种现象和后皮质区域的轻微延迟反应。不同受试者的辅助实验测量了与新CDB任务相关的潮气末CO2变化，并将所得反应性图与使用传统的4%CO2气体吸入高碳酸血症挑战获得的反应性图进行了定量比较。CDB任务导致平均潮气末CO2降低6.0±1.1和10.5±2.6 mmHg之间，大约三次呼吸后水平恢复到基线，证明该任务确实导致短暂的轻度低碳酸血症。结果反应性地图之间的相似性表明CDB提供了一种替代方法映射脑血管反应性。
We offer a new method for characterizing the magnitude and dynamics of the vascular response to changes in arterial gas tensions using noninvasive blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) and paradigms appropriate for clinical settings. A novel respiratory task, “Cued Deep Breathing” (CDB), consisting of two consecutive cycles of cued breaths, has been developed to cause transient hypocapnia, and consequently a strong, short-lived BOLD signal decrease. Data from CDB hypocapnia paradigms and traditional breath-holding hypercapnia paradigms were analyzed on a voxelwise basis to map regional heterogeneity in magnitude and timing parameters. The tasks caused comparable absolute BOLD percent signal changes (~0.5-3.0% in gray matter) and both datasets suggested consistent regional heterogeneity in the response timing: parts of the basal ganglia, particularly the putamen, and bilateral areas of medial cortex reached their maximum signal change several seconds earlier than remaining cortical gray matter voxels. This phenomenon and a slightly delayed response in posterior cortical regions were present in group-maps of ten healthy subjects. An auxiliary experiment in different subjects measured end-tidal CO2 changes associated with the new CDB task and quantitatively compared the resulting reactivity maps with those acquired using a traditional hypercapnia challenge of 4% CO2 gas inspiration. The CDB task caused average end-tidal CO2 decreases between 6.0±1.1 and 10.5±2.6 mmHg, with levels returning to baseline after approximately three breaths, giving evidence that the task indeed causes transient mild hypocapnia. Similarity between resulting reactivity maps suggest CDB offers an alternative method for mapping cerebrovascular reactivity.
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影响因子：
3.3
作者：
McKay, LC;Evans, KC;Corfield, DR
通讯作者：
Corfield, DR
影响因子：
4.8
作者：
Smith, SM
通讯作者：
Smith, SM
DOI：
10.1097/00004647-200008000-00011
发表时间：
2000-08-01
影响因子：
6.3
作者：
Ito, H;Yokoyama, I;Kanno, I
通讯作者：
Kanno, I
影响因子：
1.3
作者：
DUYN, JH;VANGELDEREN, P;MOONEN, CTW
通讯作者：
MOONEN, CTW
DOI：
10.1097/01.wcb.0000037546.46809.ca
发表时间：
2003-01-01
影响因子：
6.3
作者：
Shiino, A;Morita, Y;Inubushi, T
通讯作者：
Inubushi, T