Tissue signals imprint ILC2 identity with anticipatory function.
Tissue signals imprint ILC2 identity with anticipatory function.
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DOI：
10.1038/s41590-018-0201-4
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发表时间：
2018-10
影响因子：
30.5
通讯作者：
Locksley RM
中科院分区：
文献类型：
--
作者：
Ricardo-Gonzalez RR;Van Dyken SJ;Schneider C;Lee J;Nussbaum JC;Liang HE;Vaka D;Eckalbar WL;Molofsky AB;Erle DJ;Locksley RM
第2组先天性淋巴样细胞（ILC 2）全身分布并响应于多种刺激产生2型细胞因子，包括上皮细胞因子白细胞介素（IL）-25、IL-33和胸腺基质淋巴细胞生成素（TSLP）。然而，即使在IL-25、IL-33 R和TSLPR联合缺乏的情况下，来自不同组织的ILC 2的转录谱也根据其来源组织对ILC 2进行分组。单细胞分析证实了组织组织转录组，并确定了表达不同激活受体的ILC 2亚群，包括皮肤ILC 2的主要亚群，其优先被IL-18激活。在无菌小鼠中，组织ILC 2亚群的数量和表达没有改变，这表明内源性的组织来源的信号通过控制激活受体的不同模式的表达来驱动ILC 2亚群的成熟，从而预测在以后的生活中发生的组织特异性扰动。
Group 2 innate lymphoid cells (ILC2s) are distributed systemically and produce type 2 cytokines in response to a variety of stimuli, including the epithelial cytokines interleukin (IL)-25, IL-33, and thymic stromal lymphopoietin (TSLP). Transcriptional profiling of ILC2s from different tissues, however, grouped ILC2s according to their tissue of origin, even in the setting of combined IL-25, IL-33R and TSLPR-deficiency. Single-cell profiling confirmed a tissue-organizing transcriptome and identified ILC2 subsets expressing distinct activating receptors, including the major subset of skin ILC2s, which were activated preferentially by IL-18. Tissue ILC2 subsets were unaltered in number and expression in germ-free mice, suggesting that endogenous, tissue-derived signals drive the maturation of ILC2 subsets by controlling expression of distinct patterns of activating receptors, thus anticipating tissue-specific perturbations occurring later in life.
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影响因子：
64.5
作者：
Schneider C;O'Leary CE;von Moltke J;Liang HE;Ang QY;Turnbaugh PJ;Radhakrishnan S;Pellizzon M;Ma A;Locksley RM
通讯作者：
Locksley RM
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
30.8
作者：
Demenais F;Margaritte-Jeannin P;Barnes KC;Cookson WOC;Altmüller J;Ang W;Barr RG;Beaty TH;Becker AB;Beilby J;Bisgaard H;Bjornsdottir US;Bleecker E;Bønnelykke K;Boomsma DI;Bouzigon E;Brightling CE;Brossard M;Brusselle GG;Burchard E;Burkart KM;Bush A;Chan-Yeung M;Chung KF;Couto Alves A;Curtin JA;Custovic A;Daley D;de Jongste JC;Del-Rio-Navarro BE;Donohue KM;Duijts L;Eng C;Eriksson JG;Farrall M;Fedorova Y;Feenstra B;Ferreira MA;Australian Asthma Genetics Consortium (AAGC) collaborators;Freidin MB;Gajdos Z;Gauderman J;Gehring U;Geller F;Genuneit J;Gharib SA;Gilliland F;Granell R;Graves PE;Gudbjartsson DF;Haahtela T;Heckbert SR;Heederik D;Heinrich J;Heliövaara M;Henderson J;Himes BE;Hirose H;Hirschhorn JN;Hofman A;Holt P;Hottenga J;Hudson TJ;Hui J;Imboden M;Ivanov V;Jaddoe VWV;James A;Janson C;Jarvelin MR;Jarvis D;Jones G;Jonsdottir I;Jousilahti P;Kabesch M;Kähönen M;Kantor DB;Karunas AS;Khusnutdinova E;Koppelman GH;Kozyrskyj AL;Kreiner E;Kubo M;Kumar R;Kumar A;Kuokkanen M;Lahousse L;Laitinen T;Laprise C;Lathrop M;Lau S;Lee YA;Lehtimäki T;Letort S;Levin AM;Li G;Liang L;Loehr LR;London SJ;Loth DW;Manichaikul A;Marenholz I;Martinez FJ;Matheson MC;Mathias RA;Matsumoto K;Mbarek H;McArdle WL;Melbye M;Melén E;Meyers D;Michel S;Mohamdi H;Musk AW;Myers RA;Nieuwenhuis MAE;Noguchi E;O'Connor GT;Ogorodova LM;Palmer CD;Palotie A;Park JE;Pennell CE;Pershagen G;Polonikov A;Postma DS;Probst-Hensch N;Puzyrev VP;Raby BA;Raitakari OT;Ramasamy A;Rich SS;Robertson CF;Romieu I;Salam MT;Salomaa V;Schlünssen V;Scott R;Selivanova PA;Sigsgaard T;Simpson A;Siroux V;Smith LJ;Solodilova M;Standl M;Stefansson K;Strachan DP;Stricker BH;Takahashi A;Thompson PJ;Thorleifsson G;Thorsteinsdottir U;Tiesler CMT;Torgerson DG;Tsunoda T;Uitterlinden AG;van der Valk RJP;Vaysse A;Vedantam S;von Berg A;von Mutius E;Vonk JM;Waage J;Wareham NJ;Weiss ST;White WB;Wickman M;Widén E;Willemsen G;Williams LK;Wouters IM;Yang JJ;Zhao JH;Moffatt MF;Ober C;Nicolae DL
通讯作者：
Nicolae DL
影响因子：
5.5
作者：
Bando, Jennifer K.;Nussbaum, Jesse C.;Locksley, Richard M.
通讯作者：
Locksley, Richard M.
第一次呼吸诱导的 2 型通路塑造肺部免疫环境。
影响因子：
8.8
作者：
Saluzzo S;Gorki AD;Rana BMJ;Martins R;Scanlon S;Starkl P;Lakovits K;Hladik A;Korosec A;Sharif O;Warszawska JM;Jolin H;Mesteri I;McKenzie ANJ;Knapp S
通讯作者：
Knapp S