Sarcopenia in stroke-facts and numbers on muscle loss accounting for disability after stroke.
Sarcopenia in stroke-facts and numbers on muscle loss accounting for disability after stroke.
复制标题
中风的肌肉减少症和肌肉损失的数字，占中风后残疾的核能。
DOI：
10.1007/s13539-011-0024-8
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Doehner W
中科院分区：
文献类型：
--
作者：
Scherbakov N;Doehner W
中风是西方国家第三大致死原因和致残原因。超过60%的患者仍然残疾，50%的患者患有某些偏瘫，30%的患者在没有帮助的情况下仍然无法行走。骨骼肌是中风致残的主要作用器官。然而，这种残疾传统上被归因于脑损伤本身，而对肌肉组织的结构、代谢和功能方面的关注较少。偏瘫性中风会导致各种肌肉异常。去神经支配、废用、炎症、重塑和痉挛的结合导致了肌肉组织表型改变和萎缩的复杂模式。虽然中风后肌肉退化的分子机制还不完全清楚，但中风相关的肌肉减少症可能是一个结论。神经再生，纤维类型移位，废用性萎缩和局部炎症激活只是需要解决的一些关键特征。尽管对卒中后最佳恢复很重要，但卒中相关的肌肉减少症在目前的卒中治疗和康复指南中并未得到认可。总共不超过500例患者构成了卒中后临床肌肉变化的所有现有证据的基础。卒中后肌肉病理和治疗策略缺乏强有力的证据，这需要通过跨学科的综合方法来解决。
Stroke is the third leading cause of death and the leading cause of disability in Western countries. More than 60% of patients remain disabled, 50% of patients suffer from some hemiparesis and 30% remain unable to walk without assistance. The skeletal muscle is the main effector organ accountable for disability in stroke. This disability is, however, traditionally attributed to the brain injury itself and less attention is paid to structural, metabolic and functional aspects of muscle tissue. Hemiparetic stroke leads to various muscle abnormalities. A combination of denervation, disuse, inflammation, remodelling and spasticity account for a complex pattern of muscle tissue phenotype change and atrophy. While the molecular mechanisms of muscle degradation after stroke are only incompletely understood, a stroke-related sarcopenia may be concluded. Reinnervation, fiber-type shift, disuse atrophy and local inflammatory activation are only some of the key features to be addressed. Despite the importance for optimum post stroke recovery, stroke-related sarcopenia is not recognised in current guidelines for stroke therapy and rehabilitation. A total of not more than 500 patients forms the basis for all available evidence on clinical muscle changes after stroke. A lack of robust evidence on muscle pathology after stroke and on treatment strategies becomes apparent that needs to be addressed in an interdisciplinary integrated approach.
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影响因子：
8.9
作者：
Lenk, Karsten;Schuler, Gerhard;Adams, Volker
通讯作者：
Adams, Volker
DOI：
10.1007/s13539-010-0016-0
发表时间：
2010-12
期刊：
Journal of cachexia, sarcopenia and muscle
影响因子：
--
作者：
Kilgour RD;Vigano A;Trutschnigg B;Hornby L;Lucar E;Bacon SL;Morais JA
通讯作者：
Morais JA
DOI：
10.1016/s1052-3057(03)00042-9
发表时间：
2003-05-01
期刊：
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
影响因子：
--
作者：
Kelly-Hayes, Margaret;Beiser, Alexa;Wolf, Philip A
通讯作者：
Wolf, Philip A
影响因子：
3
作者：
Harris, ML;Polkey, MI;Moxham, J
通讯作者：
Moxham, J
影响因子：
8.3
作者：
Heuschmann, Peter U.;Di Carlo, Antonio;Wolfe, Charles D. A.
通讯作者：
Wolfe, Charles D. A.