Neurexin regulates nighttime sleep by modulating synaptic transmission.
Neurexin regulates nighttime sleep by modulating synaptic transmission.
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Neurexin 通过调节突触传递来调节夜间睡眠
DOI：
10.1038/srep38246
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发表时间：
2016-12-01
影响因子：
4.6
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Tong H;Li Q;Zhang ZC;Li Y;Han J
Neurexins是参与突触形成和突触传递的细胞黏附分子。神经毒素基因的突变与自闭症谱系障碍(ASD)有关，而自闭症谱系障碍通常与睡眠问题有关。然而，神经红素介导的突触传递在睡眠调节中的作用尚不清楚。在这里，我们表明，缺乏果蝇α-Neuresin同源物显著降低了夜间睡眠的数量和质量，并破坏了睡眠的动态平衡。我们报道了在果蝇蘑菇体(MB)αβ神经元中表达的神经毒素对夜间睡眠是必不可少的。我们证明了nneurexin突变体夜间睡眠减少是由于αβ神经元输出受损，并表明neurexin功能偶联钙通道来调节突触传递。最后，我们确定αβ表面(αβS)神经元释放乙酰胆碱和短神经肽F(SNPF)，而αβ核心(αβc)神经元释放sNPF以促进夜间睡眠。我们的研究结果表明，神经氨酸通过调节αβ神经元的突触传递来调节夜间睡眠。这项研究阐明了突触传递在睡眠调节中的作用，并可能为自闭症患者睡眠障碍的机制提供见解。
Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of theDrosophilaα-neurexin homolog significantly reduces the quantity and quality of nighttime sleep and impairs sleep homeostasis. We report that neurexin expression inDrosophilamushroom body (MB) αβ neurons is essential for nighttime sleep. We demonstrate that reduced nighttime sleep inneurexinmutants is due to impaired αβ neuronal output, and show that neurexin functionally couples calcium channels (Cac) to regulate synaptic transmission. Finally, we determine that αβ surface (αβs) neurons release both acetylcholine and short neuropeptide F (sNPF), whereas αβ core (αβc) neurons release sNPF to promote nighttime sleep. Our findings reveal that neurexin regulates nighttime sleep by mediating the synaptic transmission of αβ neurons. This study elucidates the role of synaptic transmission in sleep regulation, and might offer insights into the mechanism of sleep disturbances in patients with autism disorders.
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影响因子：
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作者：
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通讯作者：
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