Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.
Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance.
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DOI：
10.3390/md8020313
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发表时间：
2010-02-23
期刊：
影响因子：
5.4
通讯作者：
Proksch P
中科院分区：
文献类型：
--
作者：
Ebada SS;Lin W;Proksch P
海洋生态系统（占地球表面的70%以上）是不可估量的生物活动和巨大化学实体的连续资源。这种多样性为具有潜在生物活性的化合物提供了独特的来源，这些化合物可能导致潜在的新药候选物。许多海洋生物体是软体的和/或固着的。因此，它们产生了有毒的次级代谢物，或从微生物中获得它们，以保护自己免受捕食者的侵害。在过去的30-40年里，海洋无脊椎动物一直是世界各地科学家的一个有吸引力的研究课题。相对少数的海洋植物、动物和微生物已经产生了15 000多种天然产物，包括许多具有潜在制药潜力的化合物。其中一些已经在药物市场上推出，如Prialt®（齐考诺肽;强效镇痛药）和Yondelis®（曲贝替丁或ET-743;抗肿瘤药），而另一些已经进入临床试验，例如，alpidin和kahalalide F.在众多的海洋天然产物中，萜类化合物是迄今为止报道和发现的最常见的化合物之一。二萜类化合物（C25）和三萜类化合物（C30）是海绵中常见的化合物，具有显著的生物活性。本文综述了海绵中二萜和三萜类化合物的生物活性。
Marine ecosystems (>70% of the planet’s surface) comprise a continuous resource of immeasurable biological activities and immense chemical entities. This diversity has provided a unique source of chemical compounds with potential bioactivities that could lead to potential new drug candidates. Many marine-living organisms are soft bodied and/or sessile. Consequently, they have developed toxic secondary metabolites or obtained them from microorganisms to defend themselves against predators. For the last 30–40 years, marine invertebrates have been an attractive research topic for scientists all over the world. A relatively small number of marine plants, animals and microbes have yielded more than 15,000 natural products including numerous compounds with potential pharmaceutical potential. Some of these have already been launched on the pharmaceutical market such as Prialt® (ziconotide; potent analgesic) and Yondelis® (trabectedin or ET-743; antitumor) while others have entered clinical trials, e.g., alpidin and kahalalide F. Amongst the vast array of marine natural products, the terpenoids are one of the more commonly reported and discovered to date. Sesterterpenoids (C25) and triterpenoids (C30) are of frequent occurrence, particularly in marine sponges, and they show prominent bioactivities. In this review, we survey sesterterpenoids and triterpenoids obtained from marine sponges and highlight their bioactivities.
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