Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005-2006.
Prevalence of pre-diabetes and its association with clustering of cardiometabolic risk factors and hyperinsulinemia among U.S. adolescents: National Health and Nutrition Examination Survey 2005-2006.
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DOI：
10.2337/dc08-1128
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发表时间：
2009-02
期刊：
影响因子：
16.2
通讯作者：
Mokdad AH
中科院分区：
文献类型：
--
作者：
Li C;Ford ES;Zhao G;Mokdad AH
目的：空腹血糖受损(IFG)和/或糖耐量受损(IGT)被认为是“糖尿病前期”。我们使用具有全国代表性的样本数据估计了美国青少年中IFG、IGT和糖尿病前期的患病率。研究设计和方法--我们分析了2005-2006年全国健康和营养检查调查中年龄在12-19岁的参与者的数据。我们使用空腹血糖和口服葡萄糖耐量试验中的2小时血糖来评估IFG、IGT和糖尿病前期的患病率，并使用对数二项模型估计患病率(PR)和95%的顺式。结果：未调整的IFG、IGT和糖尿病前期的患病率分别为13.1%、3.4%和16.1%。男孩的糖尿病前期患病率是女孩的2.4倍(95%可信区间1.3-4.3)。非西班牙裔黑人的发病率低于非西班牙裔白人(PR 0.6，95%CI 0.4-0.9)。16~19岁青少年患病率低于12~15岁青少年(0.6，0.4~0.9)。超重青少年的比例是正常体重青少年的2.6倍(1.3-5.1)。有两个或两个以上心脏代谢危险因素的青少年的发病率是没有危险因素的青少年的2.7倍(1.5-4.8)。患有高胰岛素血症的青少年患病率(2.2-7.4)是未患高胰岛素血症的青少年的四倍。在调整高胰岛素血症后，超重或心脏代谢危险因素的数量与糖尿病前期均无显著关联。结论--糖尿病前期在青少年中非常普遍。高胰岛素血症与糖尿病前期独立相关，可能解释了超重和心脏代谢危险因素聚集与糖尿病前期的关联。
OBJECTIVE—Impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) are considered to constitute “pre-diabetes.” We estimated the prevalence of IFG, IGT, and pre-diabetes among U.S. adolescents using data from a nationally representative sample. RESEARCH DESIGN AND METHODS—We analyzed data from participants aged 12–19 years in the National Health and Nutrition Examination Survey 2005–2006. We used fasting plasma glucose and 2-h glucose during an oral glucose tolerance test to assess the prevalence of IFG, IGT, and pre-diabetes and used the log-binomial model to estimate the prevalence ratios (PRs) and 95% CIs. RESULTS—The unadjusted prevalences of IFG, IGT, and pre-diabetes were 13.1, 3.4, and 16.1%, respectively. Boys had a 2.4-fold higher prevalence of pre-diabetes than girls (95% CI 1.3–4.3). Non-Hispanic blacks had a lower rate than non-Hispanic whites (PR 0.6, 95% CI 0.4–0.9). Adolescents aged 16–19 years had a lower rate than those aged 12–15 years (0.6, 0.4–0.9). Overweight adolescents had a 2.6-fold higher rate than those with normal weight (1.3–5.1). Adolescents with two or more cardiometabolic risk factors had a 2.7-fold higher rate than those with none (1.5–4.8). Adolescents with hyperinsulinemia had a fourfold higher prevalence (2.2–7.4) than those without. Neither overweight nor number of cardiometabolic risk factors was significantly associated with pre-diabetes after adjustment for hyperinsulinemia. CONCLUSIONS—Pre-diabetes was highly prevalent among adolescents. Hyperinsulinemia was independently associated with pre-diabetes and may account for the association of overweight and clustering of cardiometabolic risk factors with pre-diabetes.
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影响因子：
168.9
作者：
Weiss, R;Dufour, S;Caprio, S
通讯作者：
Caprio, S
影响因子：
16.2
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--
影响因子：
16.2
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
通讯作者：
Reaven, Gerald M.
影响因子：
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作者：
Barr, Elizabeth L. M.;Zimmet, Paul Z.;Shaw, Jonathan E.
通讯作者：
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影响因子：
8
作者：
Williams, DE;Cadwell, BL;Imperatore, G
通讯作者：
Imperatore, G