Diabetes and associated complications in the South Asian population.
Diabetes and associated complications in the South Asian population.
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DOI：
10.1007/s11886-014-0476-5
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发表时间：
2014-05
影响因子：
3.7
通讯作者：
Kanaya, Alka M.
中科院分区：
文献类型：
--
作者：
Shah, Arti;Kanaya, Alka M.
关键词：
南亚人糖尿病患病率的增加具有重大的健康和经济影响。由于生物和生活方式的因素，南亚人易患糖尿病。此外，糖尿病并发症的发病率和死亡率也很高，尤其是冠状动脉疾病、脑血管疾病和慢性肾脏疾病。因此，了解南亚人糖尿病危险因素及其相关并发症的病理生理学和遗传学对于遏制糖尿病流行至关重要。有了这一认识，就可以实施和进一步发展适当的筛查、预防和治疗策略。在这篇综述中，我们详细讨论了南亚人易患糖尿病的生物和生活方式因素，并综述了南亚人糖尿病微血管和大血管并发症的流行病学和病理生理学。我们还回顾了南亚人正在进行和已完成的糖尿病预防和管理研究。
The increasing prevalence of diabetes in South Asians has significant health and economic implications. South Asians are predisposed to the development of diabetes due to biologic and lifestyle factors. Furthermore, they experience significant morbidity and mortality from complications of diabetes, most notably coronary artery disease, cerebrovascular disease and chronic kidney disease. Therefore, understanding the pathophysiology and genetics of diabetes risk factors and its associated complications in South Asians is paramount to curbing the diabetes epidemic. With this understanding, the appropriate screening, preventative and therapeutic strategies can be implemented and further developed. In this review, we discuss in detail the biologic and lifestyle factors that predispose South Asians to diabetes and review the epidemiology and pathophysiology of microvascular and macrovascular complications of diabetes in South Asians. We also review the ongoing and completed diabetes prevention and management studies in South Asians.
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