Impaired response of plasma vasopressin to orthostatic stress in patients with congestive heart failure.
Impaired response of plasma vasopressin to orthostatic stress in patients with congestive heart failure.
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充血性心力衰竭患者血浆加压素对体位应激的反应受损。
DOI：
10.1016/s0735-1097(83)80333-7
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发表时间：
1983
影响因子：
24
通讯作者：
Cohn,JN
中科院分区：
文献类型：
--
作者：
Goldsmith,SR;Francis,GS;Levine,TB;CowleyJr,AW;Cohn,JN
精氨酸加压素是一种有效的血管收缩和体水调节剂，在充血性心力衰竭患者的血浆中经常增加。其他神经体液控制网络，如交感神经系统和肾素-血管紧张素系统，在充血性心力衰竭时也表现出活动增加，但无法对生理性应激做出正常反应，如立位倾斜。为评价心力衰竭患者血浆加压素对立位的反应，测定了15例充血性心力衰竭患者在被动直立倾斜前、10min和45min时的血浆加压素水平，并与9例正常对照组进行比较。用放射免疫法测定精氨酸加压素。正常人血浆精氨酸加压素在对照组为5.3±2.3pg/ml，10min时无明显变化，45min时显著升高至7.0±2.5pg/ml(p<；0.05)。相比之下，充血性心力衰竭患者的精氨酸加压素水平与对照组的11.6±5.5 pg/ml相比没有显著变化。正常受试者血浆去甲肾上腺素和肾素活性均有所增加，但充血性心力衰竭患者的血浆精氨酸加压素和去甲肾上腺素和肾素活性不会因直立倾斜而增加。因此，充血性心力衰竭患者血浆精氨酸加压素与血浆去甲肾上腺素和肾素活性一样，不会因直立倾斜而增加。其原因并不明显，但可能与充血性心力衰竭时血浆加压素的反射控制异常或直立位时激素清除异常有关。
Arginine vasopressin, a potent vasoconstrictor and regulator of body water, is frequently increased in the plasma of patients with congestive heart failure. Other neurohumoral control networks, such as the sympathetic nervous system and the renin-angiotensin system, also demonstrate increased activity in congestive heart failure, but fail to respond normally to physiologic stress, such as orthostatic tilt. To assess the response of plasma vasopressin to orthostasis in heart failure, vasopressin was measured before and at 10 and 45 minutes during passive upright tilt in 15 patients with congestive heart failure and their response was compared with that in 9 normal control subjects. Arginine vasopressin was measured by radioimmunoassay. In the normal subjects, plasma arginine vasopressin was 5.3 ± 2.3 pg/ml at control, was unchanged at 10 minutes, but significantly increased to 7.0 ± 2.5 pg/ml at 45 minutes (p < 0.05). In contrast, patients with congestive heart failure showed no significant changes in arginine vasopressin levels from the control levels of 11.6 ± 5.5 pg/ml. Both plasma norepinephrine and renin activity increased in the normal subjects, but failed to increase from higher baselines in patients with congestive heart failure.Thus, plasma arginine vasopressin, like plasma norepinephrine and renin activity, does not increase in response to upright tilt in patients with congestive heart failure. The explanation is not evident but could involve either abnormalities in reflex control of plasma vasopressin in congestive heart failure or in clearance of the hormone during orthostasis.
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由直立性和普萘洛尔定义的肾素和加压素释放之间的相互关系。
影响因子：
15.9
作者：
R. Davies;M. Forsling;J. Slater
通讯作者：
J. Slater
多巴胺作为人类血管蛋白释放抑制剂的证据
影响因子：
3.2
作者：
S. Lightman;M. Forsling
通讯作者：
M. Forsling
慢性充血性心力衰竭犬左心房牵张感受器的适应机制。
影响因子：
15.9
作者：
I. Zucker;A. Earle;J. P. Gilmore
通讯作者：
J. P. Gilmore
充血性心力衰竭患者体位性局部血流反应。
影响因子：
24
作者：
Goldsmith,SR;Francis,GS;Levine,TB;Cohn,JN
通讯作者：
Cohn,JN
加压素和去甲肾上腺素对人体较低身体负压的反应。
DOI：
10.1152/ajpheart.1982.243.6.h970
发表时间：
1982
期刊：
The American journal of physiology
影响因子：
--
作者：
Goldsmith,SR;Francis,GS;Cowley,AW;Cohn,JN
通讯作者：
Cohn,JN