Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium.
Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium.
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DOI：
10.1007/s10654-018-0409-5
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发表时间：
2018-12
影响因子：
13.6
通讯作者：
Boccia S
中科院分区：
文献类型：
--
作者：
Leoncini E;Vukovic V;Cadoni G;Giraldi L;Pastorino R;Arzani D;Petrelli L;Wünsch-Filho V;Toporcov TN;Moyses RA;Matsuo K;Bosetti C;La Vecchia C;Serraino D;Simonato L;Merletti F;Boffetta P;Hashibe M;Lee YA;Boccia S
复发和第二原发癌（SPC）仍然是头颈癌（HNC）长期生存的主要障碍。我们的目的是评估已建立的人口统计学、生活方式相关的HNC风险因素和临床数据是否与HNC的复发和SPC相关。我们进行了一项多中心研究，使用来自国际头颈癌流行病学联盟米兰、罗马、西欧、圣保罗和日本的五项研究成员的数据，共4005例HNC病例，中位年龄为59岁（四分位距52-67）。估计复发和SPC的多变量风险比（HR）和95%置信区间（CI）。在随访期间，1161例（29%）患者复发，343例（8.6%）发生SPC。晚期肿瘤分期与HNC总体复发风险增加相关（HR = 1.76，95% CI 1.41-2.19）。与男性相比，女性喉癌患者的复发风险降低（HR = 0.39，95% CI：0.24-0.74）。关于SPC的预测因素，高龄（HR = 1.02; 95%CI：1.00-1.04）和饮酒（> 1杯/天，HR = 2.11; 95%CI：1.13-3.94）增加喉癌患者SPC的风险。此外，在HNC总体组（HR = 1.68; 95% CI：1.13-2.51）和口咽癌组（HR = 1.74; 95% CI：1.02-2.98）中，女性SPC的风险较高。肿瘤分期和男性（仅喉）是HNC患者癌症复发的阳性预测因子。SPC的预测因素是喉癌病例中的高龄和饮酒，口咽癌和HNC的总体预测因素是女性。
Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00–1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95% CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall.
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DOI：
10.1097/coc.0b013e318059adfc
发表时间：
2007-10-01
影响因子：
2.6
作者：
Garces, Yolanda I.;Schroeder, Darrell R.;Hurt, Richard D.
通讯作者：
Hurt, Richard D.
DOI：
10.1093/jnci/djk179
发表时间：
2007-05-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Hashibe, Mia;Brennan, Paul;Boffetta, Paolo
通讯作者：
Boffetta, Paolo
影响因子：
2.3
作者：
Do, KA;Johnson, MM;Spitz, MR
通讯作者：
Spitz, MR
影响因子：
2.6
作者：
Tiwana, Manpreet S.;Hay, John;Olson, Robert A.
通讯作者：
Olson, Robert A.
影响因子：
4.8
作者：
D'Souza G;Anantharaman D;Gheit T;Abedi-Ardekani B;Beachler DC;Conway DI;Olshan AF;Wunsch-Filho V;Toporcov TN;Ahrens W;Wisniewski K;Merletti F;Boccia S;Tajara EH;Zevallos JP;Levi JE;Weissler MC;Wright S;Scelo G;Mazul AL;Tommasino M;Cadoni G;Brennan P
通讯作者：
Brennan P