Evolving mechanical properties of a model of abdominal aortic aneurysm
Evolving mechanical properties of a model of abdominal aortic aneurysm
复制标题
腹主动脉瘤模型机械特性的演变
DOI：
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发表时间：
2009
影响因子：
3.5
通讯作者：
Nicholas A. Hill
中科院分区：
文献类型：
--
作者：
P. Watton;Nicholas A. Hill
The novel three-dimensional (3D) mathematical model for the development of abdominal aortic aneurysm (AAA) of Watton et al. Biomech Model Mechanobiol 3(2): 98–113, (2004) describes how changes in the micro-structure of the arterial wall lead to the development of AAA, during which collagen remodels to compensate for loss of elastin. In this paper, we examine the influence of several of the model’s material and remodelling parameters on growth rates of the AAA and compare with clinical data. Furthermore, we calculate the dynamic properties of the AAA at different stages in its development and examine the evolution of clinically measurable mechanical properties. The model predicts that the maximum diameter of the aneurysm increases exponentially and that the ratio of systolic to diastolic diameter decreases from 1.13 to 1.02 as the aneurysm develops; these predictions are consistent with physiological observations of Vardulaki et al. Br J Surg 85:1674–1680 (1998) and Lanne et al. Eur J Vasc Surg 6:178–184 (1992), respectively. We conclude that mathematical models of aneurysm growth have the potential to be useful, noninvasive diagnostic tools and thus merit further development.
DOI：
10.1115/1.1427698
发表时间：
2002-02-01
影响因子：
1.7
作者：
Hansen, KA;Weiss, JA;Barton, JK
通讯作者：
Barton, JK
DOI：
10.1152/ajpheart.01047.2006
发表时间：
2007-03-01
影响因子：
4.8
作者：
Chien, Shu
通讯作者：
Chien, Shu
DOI：
10.1115/1.2800858
发表时间：
1999-12-01
影响因子：
1.7
作者：
Humphrey, JD
通讯作者：
Humphrey, JD