Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats.
Operant novelty seeking predicts cue-induced reinstatement following cocaine but not water reinforcement in male rats.
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DOI：
10.1007/s00213-023-06441-4
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发表时间：
2023-10
影响因子：
3.4
通讯作者：
Dietz DM
中科院分区：
文献类型：
--
作者：
Gancarz AM;Hagarty DP;Cobb MM;Kausch MA;Krieg B;Alammari N;Gilbert K;Russo J;Dietz DM
可卡因成瘾的一个重要方面是复发的高倾向，越来越多的研究调查了使个人倾向于不受控制的药物使用和复发的因素。与吸毒成瘾有关的一种人格特征是高度感觉寻求，即对新奇感觉/体验的偏好。在感觉寻求的动物模型中，操作性新奇寻求预测药物自我给药的获得。这项研究的主要目的是评估这样一种假设，即对新的感觉刺激的强化效应的敏感性预示着吸毒行为的更密集方面，如复发。首先对大鼠进行操作性新奇探索测试，在此过程中，反应会产生复杂的视觉/听觉刺激。接下来，训练老鼠对提示灯发出的水/可卡因增强剂做出反应。最后，在没有离散线索的情况下，大鼠被暴露在灭绝中，随后在线索诱导的恢复过程中进行单次测试，在此期间，积极的反应导致先前与水/可卡因输送配对的线索。目前的研究表明，在自我给药和离散线索诱导的恢复过程中，产生新感觉刺激的操作反应与对可卡因的反应呈正相关，但与灭绝过程中的表现无关。观察到了一种不同的关联模式，以获得自然的奖励，在这种情况下，水强化。在这里，新颖性寻求的程度也与对水强化和消亡反应的反应有关；然而，在线索诱导的恢复测试中，操作性新颖性寻求与对水线索的反应不相关。综上所述，这种不协调的关系表明了天然和药物增强剂之间的根本差异。综上所述，我们发现操纵性新奇寻求(即感觉寻求)与对灭绝的反应性和发出可卡因可获得性信号的离散线索(即渴望)之间存在强化依赖关系，从而证明了操纵性新奇寻求模型在研究毒品寻求和复发方面的有效性。网上版载有补充材料，可在10.1007/s00213-023-06441-4查阅。
An important facet of cocaine addiction is a high propensity to relapse, with increasing research investigating factors that predispose individuals toward uncontrolled drug use and relapse. A personality trait linked to drug addiction is high sensation seeking, i.e., a preference for novel sensations/experiences. In an animal model of sensation seeking, operant novelty seeking predicts the acquisition of drug self-administration. The primary goal of this research was to evaluate the hypothesis that sensitivity to the reinforcing effects of novel sensory stimuli predicts more intensive aspects of drug-taking behaviors, such as relapse. Rats were first tested for Operant Novelty Seeking, during which responses resulted in complex visual/auditory stimuli. Next, rats were trained to respond to water/cocaine reinforcers signaled by a cue light. Finally, rats were exposed to extinction in the absence of discrete cues and subsequently tested in a single session of cue-induced reinstatement, during which active responses resulted in cues previously paired with water/cocaine delivery. The present study showed operant responses to produce novel sensory stimuli positively correlate with responding for cocaine during self-administration and during discrete cue-induced reinstatement, but no association with performance during extinction. A different pattern of associations was observed for a natural reward, in this case, water reinforcement. Here, the degree of novelty seeking also correlated with responding to water reinforcement and extinction responding; however, operant novelty seeking did not correlate with responding to water cues during testing of cue-induced reinstatement. Taken together, the incongruence of relationships indicates an underlying difference between natural and drug reinforcers. In summary, we found a reinforcer-dependent relationship between operant novelty seeking (i.e., sensation seeking) and responsivity to extinction and discrete cues signaling availability for cocaine (i.e., craving), demonstrating the validity of the operant novelty seeking model to investigate drug seeking and relapse. The online version contains supplementary material available at 10.1007/s00213-023-06441-4.
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影响因子：
4.6
作者：
Dickson PE;Mittleman G
通讯作者：
Mittleman G
影响因子：
3
作者：
Dickson, Price E.;Mittleman, Guy
通讯作者：
Mittleman, Guy
影响因子：
10.6
作者：
Ersche, Karen D.;Turton, Abigail J.;Pradhan, Shachi;Bullmore, Edward T.;Robbins, Trevor W.
通讯作者：
Robbins, Trevor W.
影响因子：
3.4
作者：
Doran, Neal;Cook, Jessica;McChargue, Dennis;Spring, Bonnie
通讯作者：
Spring, Bonnie
DOI：
10.1007/s11121-020-01198-0
发表时间：
2021-07
期刊：
Prevention science : the official journal of the Society for Prevention Research
影响因子：
--
作者：
Freund VA;Schulenberg JE;Maslowsky J
通讯作者：
Maslowsky J