Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits.
Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits.
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DOI：
10.1016/j.biopsych.2010.06.015
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发表时间：
2010-10-15
影响因子：
10.6
通讯作者：
Robbins, Trevor W.
中科院分区：
文献类型：
--
作者：
Ersche, Karen D.;Turton, Abigail J.;Pradhan, Shachi;Bullmore, Edward T.;Robbins, Trevor W.
遗传因素与物质滥用障碍的发展有关，但先前存在的脆弱性在成瘾中的作用仍然知之甚少。冲动和寻求感觉的个性特征在慢性吸毒者中非常普遍，并与药物滥用风险增加有关。然而，目前还不清楚这些人格特征是兴奋剂依赖的原因还是影响。我们比较了30对没有明显吸毒史的兴奋剂依赖者及其亲生兄弟姐妹和30名无关、非吸毒对照志愿者的自我报告的冲动和感觉寻求水平。慢性兴奋剂使用者的兄弟姐妹报告说，他们的特征冲动水平明显高于对照组志愿者，但在寻求感觉特征方面与对照组志愿者没有区别。与他们的兄弟姐妹和对照志愿者相比，兴奋剂依赖者报告的冲动和寻求感觉的水平明显更高。这些数据表明，冲动是一种行为内表型，调节兴奋剂依赖的风险，慢性药物暴露可能会加剧这种依赖，而异常感觉寻求更有可能是兴奋剂滥用的结果。
Genetic factors have been implicated in the development of substance abuse disorders, but the role of pre-existing vulnerability in addiction is still poorly understood. Personality traits of impulsivity and sensation-seeking are highly prevalent in chronic drug users and have been linked with an increased risk for substance abuse. However, it has not been clear whether these personality traits are a cause or an effect of stimulant drug dependence. We compared self-reported levels of impulsivity and sensation-seeking between 30 sibling pairs of stimulant-dependent individuals and their biological brothers/sisters who did not have a significant drug-taking history and 30 unrelated, nondrug-taking control volunteers. Siblings of chronic stimulant users reported significantly higher levels of trait-impulsivity than control volunteers but did not differ from control volunteers with regard to sensation-seeking traits. Stimulant-dependent individuals reported significantly higher levels of impulsivity and sensation-seeking compared with both their siblings and control volunteers. These data indicate that impulsivity is a behavioral endophenotype mediating risk for stimulant dependence that may be exacerbated by chronic drug exposure, whereas abnormal sensation-seeking is more likely to be an effect of stimulant drug abuse.
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影响因子：
4.8
作者：
Matsuo, Koji;Nicoletti, Mark;Soares, Jair C.
通讯作者：
Soares, Jair C.
影响因子：
--
作者：
Merikangas, KR;Stolar, M;Rounsaville, BJ
通讯作者：
Rounsaville, BJ
影响因子：
7.6
作者：
Nader, MA;Daunais, JB;Porrino, LJ
通讯作者：
Porrino, LJ
DOI：
10.1073/pnas.0912319107
发表时间：
2010-02-23
影响因子：
11.1
作者：
Gjedde, Albert;Kumakura, Yoshitaka;Moller, Arne
通讯作者：
Moller, Arne
影响因子：
2.7
作者：
Bankston, Susan M.;Carroll, Deidra D.;Liehr, Patricia R.
通讯作者：
Liehr, Patricia R.