MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort.
MRI-based strain measurements reflect morphological changes following myocardial infarction: A study on the UK Biobank cohort.
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DOI：
10.1111/joa.13787
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发表时间：
2023-01
影响因子：
2.4
通讯作者：
Cookson, Andrew N.
中科院分区：
文献类型：
--
作者：
Mansell, Doyin S.;Sammut, Eva;Bruno, Vito D.;Ascione, Raimondo;Rodrigues, Jonathan C. L.;Gill, Harinderjit S.;Fraser, Katharine H.;Cookson, Andrew N.
在猪心肌梗死实验模型中，局部、层特异性、周向左心室应变指标已被证明比射血分数更能显示梗死后心室功能的慢性变化。因此，这种新的应变度量可能在临床上提供有用的预后信息。在这项研究中，我们计算了一个大型人类队列中现有的临床体积指数、整体菌株和新的层特异性菌株，以评估心室功能和形态学随年龄、性别和健康状况的变化。从英国生物银行获得成像和健康数据，包括健康志愿者和有心血管病史的人。总共对710人进行了分析，并按年龄、性别和健康状况分层。在健康人群和不健康人群之间，以及男性和女性之间，所有菌株指标都存在显著差异。健康男性和女性的基本周应变和总周应变存在显著差异，男性的绝对值较小（均为0.001）。65-74岁健康男性和不健康男性的左心室射血分数、收缩期末期容积、收缩期末期容积指数和中心室周应变的功能变量有显著差异（均为0.001）。这些结果表明，虽然区域环向应变在临床上可能对评估心血管健康有用，但由于这里观察到的这些值存在差异，必须注意确保临界值与年龄和性别正确地联系起来。箱线图显示健康男性和女性的基础环周菌株有统计学显著差异，特别是在45 - 54岁和65 - 74岁年龄段。基于对英国生物银行710名参与者的分析，本研究的主要发现是健康男性的基础和整体环周左心室负荷低于健康女性。将健康受试者与不健康受试者进行比较还发现，不健康受试者，尤其是65 - 74岁的男性，心室中周张力增加，射血分数降低，收缩期终容积增加。
In a porcine experimental model of myocardial infarction, a localised, layer‐specific, circumferential left ventricular strain metric has been shown to indicate chronic changes in ventricular function post‐infarction more strongly than ejection fraction. This novel strain metric might therefore provide useful prognostic information clinically. In this study, existing clinical volume indices, global strains, and the novel, layer‐specific strain were calculated for a large human cohort to assess variations in ventricular function and morphology with age, sex, and health status. Imaging and health data from the UK Biobank were obtained, including healthy volunteers and those with a history of cardiovascular illness. In total, 710 individuals were analysed and stratified by age, sex and health. Significant differences in all strain metrics were found between healthy and unhealthy populations, as well as between males and females. Significant differences in basal circumferential strain and global circumferential strain were found between healthy males and females, with males having smaller absolute values for both (all 0.001). There were significant differences in the functional variables left ventricular ejection fraction, end‐systolic volume, end‐systolic volume index and mid‐ventricular circumferential strain between healthy and unhealthy male cohorts aged 65–74 (all 0.001). These results suggest that whilst regional circumferential strains may be useful clinically for assessing cardiovascular health, care must be taken to ensure critical values are indexed correctly to age and sex, due to the differences in these values observed here. Boxplot showing statistically significant differences in basal circumferential strains between healthy males and females, particularly for age ranges 45‐54 and 65‐74. Based on an analysis of 710 participants in the UK Biobank, the major findings of this study were that healthy males have lower basal and global circumferential left ventricular strains than healthy females. Comparing healthy to unhealthy participants also found increased mid‐ventricular circumferential strains, lowered ejection fractions, and increased end‐systolic volumes in the unhealthy group, particularly for males aged 65‐74.
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DOI：
10.1016/j.mcna.2011.11.003
发表时间：
2012-01
期刊：
The Medical clinics of North America
影响因子：
--
作者：
Dhingra R;Vasan RS
通讯作者：
Vasan RS
影响因子：
14
作者：
Rodriguez-Palomares, Jose F.;Gavara, Jose;Garcia-Dorado, David
通讯作者：
Garcia-Dorado, David
影响因子：
2.9
作者：
Lee, Sun Hwa;Lee, Sang-Rok;Kim, Won-Ho
通讯作者：
Kim, Won-Ho
通过心血管磁共振特征跟踪评估的年龄和性别相关的正常左心室变形。
DOI：
10.1186/s12968-015-0123-3
发表时间：
2015-03-10
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Andre F;Steen H;Matheis P;Westkott M;Breuninger K;Sander Y;Kammerer R;Galuschky C;Giannitsis E;Korosoglou G;Katus HA;Buss SJ
通讯作者：
Buss SJ
影响因子：
20.1
作者：
STREETER, DD;SPOTNITZ, HM;SONNENBLICK, EH
通讯作者：
SONNENBLICK, EH