Longitudinally and inter-site consistent multi-atlas based parcellation of brain anatomy using harmonized atlases.
Longitudinally and inter-site consistent multi-atlas based parcellation of brain anatomy using harmonized atlases.
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DOI：
10.1016/j.neuroimage.2017.10.026
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发表时间：
2018-02-01
期刊：
影响因子：
5.7
通讯作者：
Davatzikos C
中科院分区：
文献类型：
--
作者：
Erus G;Doshi J;An Y;Verganelakis D;Resnick SM;Davatzikos C
随着纵向和多位点研究在神经影像学中变得越来越频繁，由于扫描仪模型和/或扫描仪和位点之间图像采集协议的差异，保持大脑包裹的纵向和扫描仪间一致性已成为主要挑战。我们提出了一种新的自动分割方法，专门用于在这种异构数据集中实现解剖脑结构的一致分割。我们的方法结合了特定位点的图谱创建策略和最先进的多图谱解剖标签融合框架。特定地点的地图集的计算使得它们保留每个地点的扫描仪和采集协议的图像强度特征，而地图集对以与扫描仪间采集变化一致的方式共享解剖标签。这种地图集的协调改善了后续共识标记步骤中分割的相互研究和纵向一致性。我们在巴尔的摩老龄化纵向研究（BLSA）的大量老年人样本上测试了这种方法，这些老年人使用两种扫描仪进行纵向扫描，这两种扫描仪在供应商和图像获取协议方面有所不同。我们将所提出的方法与标准的多图谱分割进行了横向和纵向分析。这种协调显著降低了与扫描仪相关的ROI体积年龄趋势差异，提高了分割的纵向一致性，并导致更高的跨扫描仪类内相关性，特别是在白质中。
As longitudinal and multi-site studies become increasingly frequent in neuroimaging, maintaining longitudinal and inter-scanner consistency of brain parcellation has become a major challenge due to variation in scanner models and/or image acquisition protocols across scanners and sites. We present a new automated segmentation method specifically designed to achieve a consistent parcellation of anatomical brain structures in such heterogeneous datasets. Our method combines a site-specific atlas creation strategy with a state-of-the-art multi-atlas anatomical label fusion framework. Site-specific atlases are computed such that they preserve image intensity characteristics of each site’s scanner and acquisition protocol, while atlas pairs share anatomical labels in a way consistent with inter-scanner acquisition variations. This harmonization of atlases improves inter-study and longitudinal consistency of segmentations in the subsequent consensus labeling step. We tested this approach on a large sample of older adults from the Baltimore Longitudinal Study of Aging (BLSA) who had longitudinal scans acquired using two scanners that vary with respect to vendor and image acquisition protocol. We compared the proposed method to standard multi-atlas segmentation for both cross-sectional and longitudinal analyses. The harmonization significantly reduced scanner-related differences in the age trends of ROI volumes, improved longitudinal consistency of segmentations, and resulted in higher across-scanner intra-class correlations, particularly in the white matter.
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DOI：
10.1016/j.ijdevneu.2013.06.004
发表时间：
2013-11
期刊：
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
影响因子：
--
作者：
Oishi K;Faria AV;Yoshida S;Chang L;Mori S
通讯作者：
Mori S
影响因子：
5.7
作者：
Jovicich J;Czanner S;Han X;Salat D;van der Kouwe A;Quinn B;Pacheco J;Albert M;Killiany R;Blacker D;Maguire P;Rosas D;Makris N;Gollub R;Dale A;Dickerson BC;Fischl B
通讯作者：
Fischl B
影响因子：
5.7
作者：
Kruggel, Frithjof;Turner, Jessica;Muftuler, L. Tugan
通讯作者：
Muftuler, L. Tugan
影响因子：
10.9
作者：
Ou, Yangming;Sotiras, Aristeidis;Paragios, Nikos;Davatzikos, Christos
通讯作者：
Davatzikos, Christos
DOI：
10.1117/12.844575
发表时间：
2010
期刊：
Proceedings of SPIE--the International Society for Optical Engineering
影响因子：
--
作者：
Roy S;Carass A;Prince JL
通讯作者：
Prince JL