Karyotypic Progression and Metastasis Formation of Human Tumors

Karyotypic Progression and Metastasis Formation of Human Tumors
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人类肿瘤的核型进展和转移形成

DOI:
10.1007/978-1-4613-2299-3_11
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发表时间:
1986
影响因子:
2.3
通讯作者:
G. Balaban
G. Balaban
中科院分区:
医学3区
文献类型:
--
作者:
P. Nowell;G. Balaban

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近年来,染色体研究对我们在许多或多个领域对基础肿瘤生物学的理解做出了重大贡献。根据许多实验室的工作,可以对肿瘤的核型改变提出四种一般说法:1)大多数肿瘤都有染色体异常,这在身体的其他细胞中是不存在的;2)在特定的肿瘤中,所有的肿瘤细胞往往具有相同的细胞遗传学变化或相关的变化;3)虽然不同肿瘤的染色体变化往往不同,但存在非随机模式,以及4)染色体异常在晚期肿瘤中更为广泛。
In recent years, chromosome studies have contributed significantly to our understanding of fundamental tumor biology in a number or areas. Based on the work from many laboratories, four general statements can be made about karyotypic alterations in neoplasia: 1) most tumors have chromosome abnormalities, which are not present in other cells of the body, 2) in a given tumor, all the neoplastic cells often have the same cytogenetic change, or related changes, 3) although chromosome alterations often differ between tumors, there are nonrandom patterns, and 4) chromosome abnormalities are more extensive in advanced tumors.
DOI: 10.1093/jnci/66.6.1021
发表时间: 1981-01-01
影响因子: 10.3
作者:
KUSYK, CJ;SESKI, JC;EDWARDS, CL
通讯作者: EDWARDS, CL
DOI: 10.1016/s0046-8177(84)80310-x
发表时间: 1984-01-01
期刊: HUMAN PATHOLOGY
影响因子: 3.3
作者:
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通讯作者: VANHORN, M
DOI: 10.1126/science.6719137
发表时间: 1984-01-01
期刊: SCIENCE
影响因子: 56.9
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人类神经母细胞瘤的克隆进化。
DOI: --
发表时间: 1983
期刊: Journal of the National Cancer Institute
影响因子: --
作者:
Feder,MK;Gilbert,F
通讯作者: Gilbert,F
DOI: 10.1126/science.6336310
发表时间: 1983-01-01
期刊: SCIENCE
影响因子: 56.9
作者:
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