Influence of parenchymal heterogeneity on airway-parenchymal interdependence.
Influence of parenchymal heterogeneity on airway-parenchymal interdependence.
复制标题
DOI：
10.1016/j.resp.2013.06.005
复制
发表时间：
2013-08-15
影响因子：
2.3
通讯作者：
Bates, Jason H. T.
中科院分区：
文献类型：
--
作者：
Ma, Baoshun;Breen, Barbara;Bates, Jason H. T.
为了评估实质异质性对气道-实质相互依赖性的影响，我们考虑了嵌入弹性实质内的圆形气道，其模型为1）六边形弹簧网络，2）三角形弹簧网络，或3）连续体。使用有限元方法模拟由于主动气道收缩引起的实质中的变形。在软组织中的弹性模量的随机扰动并没有显着影响力传递的整体模式。相比之下，当弹性模量沿从气道径向向外突出的路径沿着增加时，六边形弹簧网络模型预测随着气道收缩沿该线的力沿着显著增加，但在其他两个模型中未观察到。这些结果表明，组织异质性通常对气道-实质相互依赖的整体性质的影响最小。然而，在疤痕组织从气道壁径向排列的特殊情况下，实质扭曲力可能比以前认为的从气道壁传播得更远。
To estimate the influence of parenchymal heterogeneities on airway-parenchymal interdependence, we considered a circular airway embedded within elastic parenchyma modeled as 1) a hexagonal spring network, 2) a triangular spring network, or 3) a continuum. The deformation in the parenchyma due to active airway contraction was simulated using the finite element method. Random perturbations of elastic moduli in the parenchyma did not significantly affect the overall pattern of force transmission. By contrast, when elastic moduli were increased along a path projecting radially outward from the airway, the hexagonal spring network model predicted significantly increased force along this line as the airway contracted, but this was not observed in other two models. These results indicate that tissue heterogeneities generally have minimal effect on the global nature of airway-parenchymal interdependence. However, in the exceptional circumstance of scar tissue aligned radially from the airway wall, parenchymal distortion forces may propagate much farther from the airway wall than was previously thought.
登录
查看更多内容
影响因子：
2.3
作者：
Breen, Barbara J.;Donovan, Graham M.;Tawhai, Merryn H.
通讯作者：
Tawhai, Merryn H.
DOI：
10.1002/cnm.1386
发表时间：
2010-07-01
影响因子：
2.1
作者：
Burrowes, K. S.;Tawhai, M. H.
通讯作者：
Tawhai, M. H.
影响因子：
3.8
作者：
Kaczka, David W.;Cao, Kunlin;Simon, Brett A.
通讯作者：
Simon, Brett A.
影响因子：
3.3
作者：
LAIFOOK, SJ;HYATT, RE
通讯作者：
HYATT, RE
影响因子：
3.8
作者：
Adler, A;Bates, JHT
通讯作者：
Bates, JHT