Mammographic breast density and serum phytoestrogen levels.
Mammographic breast density and serum phytoestrogen levels.
复制标题
乳房X线乳房密度和血清植物雌激素水平。
DOI：
10.1080/01635581.2012.707279
复制
发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Trentham-Dietz A
中科院分区：
文献类型：
--
作者：
Lowry SJ;Sprague BL;Aiello Bowles EJ;Hedman CJ;Hemming J;Hampton JM;Burnside ES;Sisney GA;Buist DS;Trentham-Dietz A
Please try later.
Some forms of estrogen are associated with breast cancer risk as well as with mammographic density (MD), a strong marker of breast cancer risk. Whether phytoestrogen intake affects breast density, however, remains unclear. We evaluated the association between serum levels of phytoestrogens and MD in postmenopausal women. We enrolled 269 women, ages 55–70 yr, who received a screening mammogram and had no history of postmenopausal hormone use. Subjects completed a survey on diet and factors related to MD and provided a blood sample for analysis of 3 phytoestrogens: genistein, daidzein, and coumestrol. We examined whether mean percent MD was related to serum level of phytoestrogens, adjusting for age and body mass index. Genistein and daidzein levels correlated with self-reported soy consumption. Mean percent MD did not differ across women with different phytoestrogen levels. For example, women with nondetectable genistein levels had mean density of 11.0% [95% confidence intervals (CI) = 9.9–12.4], compared to 10.5% (95% CI = 8.0–13.7) and 11.2% (95% CI = 8.7–14.6) for < and ≥median detectable levels, respectively. In a population with relatively low soy intake, serum phytoestrogens were not associated with mammographic density. Additional studies are needed to determine effects of higher levels, particularly given patterns of increasing phytoestrogen intake.
登录
查看更多内容
影响因子：
2.3
作者：
Horn-Ross, PL;Lee, M;Koo, J
通讯作者：
Koo, J
影响因子：
0.7
作者：
Pelekanou, Vassiliki;Leclercq, Guy
通讯作者：
Leclercq, Guy
影响因子：
7.1
作者：
Lampe, Johanna W.
通讯作者：
Lampe, Johanna W.
影响因子：
5.9
作者：
Maskarinec G;Verheus M;Tice JA
通讯作者：
Tice JA
影响因子：
3.8
作者：
Maskarinec, G;Pagano, I;Kolonel, LN
通讯作者：
Kolonel, LN