Stress and the dopaminergic reward system.
Stress and the dopaminergic reward system.
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DOI：
10.1038/s12276-020-00532-4
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发表时间：
2020-12
影响因子：
12.8
通讯作者：
Baik JH
中科院分区：
文献类型：
--
作者：
Baik JH
多巴胺通过中脑边缘多巴胺能通路调节奖赏相关行为。应激影响中脑边缘多巴胺系统的多巴胺水平和多巴胺能神经元活动。中脑边缘多巴胺能神经传递的变化对于应对压力是重要的，因为它们允许适应对各种环境刺激的行为反应。在压力暴露时，多巴胺能奖励系统的调节对于监测和选择应对压力情况的最佳过程是必要的。厌恶性应激事件可能负性调节多巴胺能奖赏系统，扰乱奖赏敏感性，这与慢性应激诱导的抑郁症密切相关。中脑边缘多巴胺系统不仅受到奖赏的刺激，也受到令人厌恶的压力刺激的刺激，这进一步增加了压力和奖赏系统之间的关系的复杂性。本文综述了压力，特别是慢性压力如何影响中脑边缘多巴胺系统的证据，并讨论了多巴胺能奖励系统在慢性压力诱导的抑郁症中的作用。大脑对压力条件的反应与处理奖励刺激的机制有关，但这种联系的性质仍然知之甚少。研究表明，动物科普急性或慢性压力的方式部分依赖于多巴胺，这是一种在大脑中产生“奖励”信号的神经递质。Ja-Hyun Baik，韩国首尔高丽大学，回顾了压力如何影响多巴胺介导的信号传导，特别是探索了这样一种假设，即压力刺激的性质特别决定了多巴胺诱导的行为以及信号在压力或奖励方面的感知方式。然而，作者也注意到围绕慢性压力的神经机制，以及压力产生的抑郁和缺乏快乐的许多未回答的问题。需要进一步的研究来了解多巴胺信号的作用。
Dopamine regulates reward-related behavior through the mesolimbic dopaminergic pathway. Stress affects dopamine levels and dopaminergic neuronal activity in the mesolimbic dopamine system. Changes in mesolimbic dopaminergic neurotransmission are important for coping with stress, as they allow adaption to behavioral responses to various environmental stimuli. Upon stress exposure, modulation of the dopaminergic reward system is necessary for monitoring and selecting the optimal process for coping with stressful situations. Aversive stressful events may negatively regulate the dopaminergic reward system, perturbing reward sensitivity, which is closely associated with chronic stress-induced depression. The mesolimbic dopamine system is excited not only by reward but also by aversive stressful stimuli, which adds further intriguing complexity to the relationship between stress and the reward system. This review focuses on lines of evidence related to how stress, especially chronic stress, affects the mesolimbic dopamine system, and discusses the role of the dopaminergic reward system in chronic stress-induced depression. The brain’s response to stressful conditions is linked to mechanisms for processing rewarding stimuli, but the nature of this connection remains poorly understood. Studies indicate that how animals cope with acute or chronic stress relies in part on dopamine, a neurotransmitter that produces ‘reward’ signals in the brain. Ja-Hyun Baik, Korea University, Seoul, South Korea, reviews how stress influences dopamine-mediated signaling, in particular exploring the hypothesis that the nature of stressful stimuli specifically determines the behavior induced by dopamine and the way signals are perceived in terms of stress or reward. However, the author also notes the many unanswered questions around the neurological mechanisms underlying chronic stress, and the depression and lack of pleasure produced by stress. Further research is needed to understand the role of dopamine signaling.
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与奖励相关行为中的多巴胺信号传导。
影响因子：
3.5
作者：
Baik JH
通讯作者：
Baik JH
影响因子：
16.2
作者：
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DOI：
10.1073/pnas.1917423117
发表时间：
2020-04-07
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1523/jneurosci.3177-10.2010
发表时间：
2010-12-08
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
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作者：
Cao JL;Covington HE 3rd;Friedman AK;Wilkinson MB;Walsh JJ;Cooper DC;Nestler EJ;Han MH
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影响因子：
6.8
作者：
Bessa JM;Morais M;Marques F;Pinto L;Palha JA;Almeida OF;Sousa N
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Sousa N