Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.
Heberden Oration 1980: aspects of the cell biology of the rheumatoid synovial lesion.
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Heberden Oration 1980：类风湿滑膜病变的细胞生物学方面。
DOI：
10.1136/ard.40.5.433
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发表时间：
1981
影响因子：
27.4
通讯作者：
Krane,SM
中科院分区：
文献类型：
--
作者：
Krane,SM
我确实很荣幸能在1980年发表希伯登演说，特别是因为瓦尔特·鲍尔是25年前的希伯登演说者。他当时是哈佛医学院的杰克逊临床医学教授和马萨诸塞州总医院的医疗服务主任。鲍尔不仅在美国，而且在全世界对风湿病学和内科学科有着巨大的影响。他还拥有出色的医术和出色的床边教师。在他职业生涯的早期，他对医学的科学基础产生了兴趣，并于1927年来到伦敦，在亨利·戴尔的实验室工作。第二年，他回到波士顿，接受塞西尔·德林克的邀请，领导一个名为罗伯特·w·洛维特纪念小组的新单位，研究导致畸形的疾病。以他特有的精力，他着手组织了一个关于骨骼和关节疾病的广泛研究项目。鲍尔认为，除了让科学家和临床医生并肩工作的重要性之外，他的部门还需要一些能够将研究和临床实践技能结合起来的人才。他的立场是，“科学的严谨性和传统的人道主义是医学的互补方面”，一些人必须尝试“同时接受这两种观点”。他认为关节疾病的奥秘可以通过结缔组织大分子的研究来解决，为此，他招募了对胶原蛋白、粘多糖和糖蛋白感兴趣的年轻科学家与他一起工作，同时他帮助和鼓励他们建立自己的独立性。其中两个人，哈佛医学院教授杰罗姆·格罗斯和罗杰·让洛兹，仍在马萨诸塞州总医院的洛维特小组从事令人兴奋的研究。
I am indeed honoured to deliver the Heberden Oration in 1980, particularly since it was 25 years ago that Walter Bauer was the Heberden Orator.'He was then Jackson professor of clinical medicine at Harvard Medical School and chief of the medical services at the Massachusetts General Hospital. Bauer had an enormous influence on the disciplines of rheumatology and internal medicine not only in the United States but throughout the world as well. He alsohad remarkable skills as a physician and was an extraordinary bedsideteacher. Early in his career he became interested in the scientific basis of medicine and in 1927 came to London to work in the laboratory of Henry Dale. The following year he returned to Boston and accepted Cecil Drinker's invitation to head a new unit called the Robert W. Lovett Memorial Group for the Study of Diseases Causing Deformities. With his characteristic energy he proceeded to organise a broad programme of research in diseases of bones and joints. 2 Bauer believed that in addition to the importance ofhaving scientists and clinicians working side by side there was a need in his department for some individuals who could combine skills in research and clinical practice. He took the position that'scientific rigor and traditional humanitarianism are complementary aspects of medicine'and that some individuals must attempt'to embrace both points of view.'3 He thought that the mysteries ofjoint diseases might be solved by study of connective tissue macromolecules, and with this aim he recruited young scientists interested in collagen, mucopolysaccharides and glycoproteins to work with him, while at the same time he helped and encouraged them to establish their own independence. Two of these individuals, Jerome Gross and Roger Jeanloz, professors at Harvard Medical School, are still engaged in exciting research in the Lovett Group at the Massachusetts General Hospital.
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人单核细胞因子对培养类风湿滑膜细胞的影响：前列腺素E2与环腺苷3′,5′-单磷酸的相互作用☆
DOI：
--
发表时间：
1979
期刊：
影响因子：
--
作者：
J. Dayer;S. Goldring;D. Robinson;S. Krane
通讯作者：
S. Krane
前列腺素调节巨噬细胞胶原酶的产生。
DOI：
10.1073/pnas.74.11.4955
发表时间：
1977
影响因子：
11.1
作者：
L. Wahl;C. Olsen;A. Sandberg;S. E. Mergenhagen
通讯作者：
S. E. Mergenhagen
人滑膜细胞：前列腺素和 1-肾上腺素的激活和脱敏。
DOI：
10.1073/pnas.72.8.3124
发表时间：
1975
影响因子：
11.1
作者：
D. Newcombe;C. Ciosek;Y. Ishikawa;J. Fahey
通讯作者：
J. Fahey
沃尔特·鲍尔，1898-1963 年
影响因子：
27.4
作者：
W. Bauer
通讯作者：
W. Bauer
甲状旁腺和甲状腺激素在固定性骨质疏松症的发展中。
影响因子：
4.8
作者：
James M. Burkhart;Jenifer Jowsey
通讯作者：
Jenifer Jowsey