The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.
The effect of vitamin D supplementation on glucose metabolism in type 2 diabetes mellitus: A systematic review and meta-analysis of intervention studies.
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DOI：
10.1016/j.jdiacomp.2017.04.019
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发表时间：
2017-07
影响因子：
3
通讯作者：
Mathioudakis N
中科院分区：
文献类型：
--
作者：
Lee CJ;Iyer G;Liu Y;Kalyani RR;Bamba N;Ligon CB;Varma S;Mathioudakis N
我们的目的是评估补充维生素D是否能改善成人2型糖尿病患者的葡萄糖代谢。检索PubMed和科克伦数据库，以查找截至2016年7月1日的随机对照试验，这些试验评估了2型糖尿病成人患者补充维生素D与糖代谢（血红蛋白A1 C（HbA 1 C）和空腹血糖（FBG）变化）之间的关系。29项试验（3324名受试者）被纳入系统性综述。在纳入荟萃分析的22项研究中，19项报告了HbA 1C，16项报告了FBG结局，15项被认为质量较差。与安慰剂相比，补充维生素D后HbA 1C略有降低（−0.32% [−0.53至−0.10]，I2 = 91.9%），但对FBG无影响（−2.33 mg/dl [−6.62至1.95]，I2 = 59.2%）。在实现维生素D缺乏症补充的研究中（n = 7），HbA 1C（− 0.45%，[−1.09至0.20]）和FBG（−7.64 mg/dl [−16.25至0.97]）的平均下降幅度更大，尽管不显著。我们发现2型糖尿病成人患者在维生素D治疗后HbA 1C适度降低，尽管研究之间存在显著异质性，FBG无差异。需要更大规模的研究来进一步评估维生素D治疗对血糖的影响，特别是在维生素D缺乏症患者中。
We aimed to assess whether vitamin D supplementation improves glucose metabolism in adults with type 2 diabetes. PubMed and Cochrane database were searched up to July 1st 2016 for randomized controlled trials that assessed the relationship between vitamin D supplementation and glucose metabolism (change in hemoglobin A1C (HbA1C) and fasting blood glucose (FBG)) among adults with type 2 diabetes. Twenty nine trials (3324 participants) were included in the systematic review. Among 22 studies included in the meta-analysis, 19 reported HbA1C, 16 reported FBG outcomes and 15 were deemed poor quality. There was a modest reduction in HbA1C (−0.32% [−0.53 to −0.10], I2 = 91.9%) compared to placebo after vitamin D supplementation but no effect on FBG (−2.33 mg/dl [−6.62 to 1.95], I2 = 59.2%). In studies achieving repletion of vitamin D deficiency (n = 7), there were greater mean reductions in HbA1C (−0.45%, [−1.09 to 0.20]) and FBG (−7.64 mg/dl [−16.25 to 0.97]) although not significant. We found a modest reduction of HbA1C after vitamin D treatment in adults with type 2 diabetes albeit with substantial heterogeneity between studies and no difference in FBG. Larger studies are needed to further evaluate the glycemic effects of vitamin D treatment especially in patients with vitamin D deficiency.
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影响因子：
5.1
作者：
Elkassaby, Shirley;Harrison, Leonard C.;Fourlanos, Spiros
通讯作者：
Fourlanos, Spiros
影响因子：
2.4
作者：
Dalan R;Liew H;Assam PN;Chan ES;Siddiqui FJ;Tan AW;Chew DE;Boehm BO;Leow MK
通讯作者：
Leow MK
影响因子：
6.3
作者：
Jafari, Tina;Faghihimani, Elham;Askari, Gholamreza
通讯作者：
Askari, Gholamreza
影响因子：
16.2
作者：
Krul-Poel, Yvonne H. M.;Westra, Sanne;Simsek, Suat
通讯作者：
Simsek, Suat
影响因子：
16.2
作者：
Kositsawat J;Freeman VL;Gerber BS;Geraci S
通讯作者：
Geraci S