Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey.

Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey.
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DOI:
10.2337/dc09-2150
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发表时间:
2010-06
期刊:
影响因子:
16.2
通讯作者:
Geraci S
Geraci S
中科院分区:
医学1区
文献类型:
--
作者:
Kositsawat J;Freeman VL;Gerber BS;Geraci S

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在美国成年人群中,维生素D状态与葡萄糖稳态指数(如A1 C所示)相关的数据很少。我们研究了参与2003-2006年国家健康和营养检查调查的9,773名成年人(年龄≥18岁)血清25羟维生素D [25(OH)D]和A1 C水平之间的关系。在考虑潜在混杂因素后,多变量线性回归分析了相关性。在35-74岁(P = 0.0045)和无糖尿病史(P = 0.0282)的受试者中,血清25(OH)D水平与A1 C水平呈负相关。这些发现支持了血清维生素D浓度,葡萄糖稳态和美国大部分成年人糖尿病演变之间的机制联系。应考虑对A1 C水平升高的人进行维生素D不足的筛查。
Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few. We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age ≥18 years old) participating in the 2003–2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35–74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282). These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered.
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