Age effects on clinical and neurocognitive risk factors for suicide attempt in depression - Findings from the AFSP lifespan study.
Age effects on clinical and neurocognitive risk factors for suicide attempt in depression - Findings from the AFSP lifespan study.
复制标题
年龄对抑郁症自杀企图的临床和神经认知危险因素的影响 - AFSP 寿命研究的结果。
DOI：
10.1016/j.jad.2021.08.014
复制
发表时间：
2021-12-01
影响因子：
6.6
通讯作者：
Szanto K
中科院分区：
文献类型：
--
作者：
Buerke M;Galfalvy H;Keilp JG;Sheftall AH;Burke AK;Bridge JA;Mann JJ;Szanto K
对自杀行为风险因素的研究通常局限于狭窄的年龄范围，因此很难确定它们在整个成人寿命中是否具有相同的相关性或效力。本研究在一个多中心样本（N=309，年龄16-80）中，对最近（过去5年）有自杀企图或无自杀企图史的抑郁症患者以及人口统计学上相似的非精神病对照组，研究了自杀行为的临床和神经认知风险因素-边缘性人格特征、攻击性、抑郁性反刍、记忆表现和语言流畅性。我们研究了这些风险因素的横截面年龄和自杀者/非自杀者差异，以及某些风险因素是否是过去自杀企图在生命早期或晚期的更突出的判别因素。计算与年龄的相关性，并根据每个危险因素及其与年龄的相互作用，使用逻辑回归对吸烟状态进行分类。几乎所有的危险因素都与年龄呈负相关。边缘特征、攻击性、记忆力和类别流畅性都能预测儿童的学习状态（p < 0.05），但这些影响在不同年龄段之间没有差异。相反，反刍和自杀企图状态之间的关联在整个生命周期中是不同的，在老年时成为过去自杀行为的一个更强的证据。横截面设计限制了我们的发展发现。尽管在症状严重程度或神经认知表现方面存在年龄相关的变化，但先前在年龄范围更有限的研究中发现的自杀行为的关键风险因素在整个成年期内都很突出。相比之下，抑郁性沉思可能在晚年尤为突出。
Studies of risk factors for suicidal behavior are typically restricted to narrow age ranges, making it difficult to determine if they have the same relevance or potency across the full adult lifespan. This study examined selected clinical and neurocognitive risk factors for suicidal behavior – borderline personality traits, aggression, depressive rumination, memory performance, and language fluency– in a multi-site sample (N=309, ages 16–80) of depressed patients with a recent (last 5 years) suicide attempt or no history of attempt, and demographically similar non-psychiatric controls. We examined cross-sectional age and attempter/non-attempter differences on these risk factors, and whether certain risk factors were more prominent discriminators of past suicide attempt earlier or later in the lifespan. Correlations with age were computed, and logistic regression was used to classify attempter status based on each risk factor and its interaction with age. Nearly all risk factors were negatively correlated with age. Borderline traits, aggression, memory, and category fluency each predicted attempter status (p < 0.05), but these effects were not different across ages. In contrast, the association between rumination and suicide attempt status differed across the lifespan, becoming a stronger discriminator of past suicidal behavior at older ages. The cross-sectional design limits our developmental findings. Despite age-related changes in symptom severity or neurocognitive performance, key risk factors for suicidal behavior previously identified in studies with more restricted age-ranges are salient throughout the adult lifespan. In contrast, depressive rumination may be particularly salient in later life.
登录
查看更多内容
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H
影响因子：
4.2
作者：
Karim HT;Ly M;Yu G;Krafty R;Tudorascu DL;Aizenstein HJ;Andreescu C
通讯作者：
Andreescu C
DOI：
10.5770/cgj.v14i3.17
发表时间：
2011-09
期刊：
Canadian geriatrics journal : CGJ
影响因子：
--
作者：
Elgamal SA;Roy EA;Sharratt MT
通讯作者：
Sharratt MT
DOI：
10.1111/j.1532-5415.1968.tb02103.x
发表时间：
1968-01-01
影响因子：
6.3
作者：
LINN, BS;LINN, MW;GUREL, L
通讯作者：
GUREL, L
DOI：
10.1093/geronb/gbz109
发表时间：
2020-01-01
影响因子：
6.2
作者：
Emery, Lisa;Sorrell, Anne;Miles, Cassidy
通讯作者：
Miles, Cassidy