Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.
Dentate Nucleus Neuronal Density: A Postmortem Study of Essential Tremor Versus Control Brains.
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DOI：
10.1002/mds.28402
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Faust PL
中科院分区：
文献类型：
--
作者：
Hartstone WG;Brown MH;Kelly GC;Tate WJ;Kuo SH;Dwork AJ;Louis ED;Faust PL
特发性震颤累及小脑，但尚未对齿状核神经元进行定量分析。目的：定量比较特发性震颤与年龄匹配的对照组齿状核神经元密度或神经元数量。用7μm厚的Luxol坚牢蓝苏木精-伊红染色切片，对25例原发性震颤患者和25例对照组的齿状核神经元密度(神经元/mm~2)进行了测定。我们还在四个特发性震颤病例和四个对照病例的子集中应用了体视学方法来估计齿状核神经元总数。海马齿状核神经元密度在原发性震颤组与对照组之间无显著差异(P=0.44)。齿状核神经元总数与神经元密度呈正相关(P=0.007.0 5)，与对照组比较差异无统计学意义(P=0.95)。在特发性震颤的浦肯野细胞群中观察到的神经元丢失，似乎与特发性震颤中的齿状核并无相似之处。
Essential tremor involves the cerebellum, yet quantitative analysis of dentate nucleus neurons has not been conducted. To quantitatively compare neuronal density or neuronal number in the dentate nucleus of essential tremor versus age-matched controls. Using a 7-μm thick Luxol fast blue hematoxylin and eosin-stained paraffin section, dentate nucleus neuronal density (neurons/mm2) was determined in 25 essential tremor cases and 25 controls. We also applied a stereological approach in a subset of four essential tremor cases and four controls to estimate total dentate nucleus neuronal number. Dentate nucleus neuronal density did not differ between essential tremor cases and controls (P = 0.44). Total dentate nucleus neuronal number correlated with neuronal density (P = 0.007) and did not differ between essential tremor cases and controls (P = 0.95). Neuronal loss, observed in the Purkinje cell population in essential tremor, did not seem to similarly involve the dentate nucleus in essential tremor.
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