Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls.
Vascular and Alzheimer's disease markers independently predict brain atrophy rate in Alzheimer's Disease Neuroimaging Initiative controls.
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DOI：
10.1016/j.neurobiolaging.2013.02.003
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发表时间：
2013-08
影响因子：
4.2
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Barnes J;Carmichael OT;Leung KK;Schwarz C;Ridgway GR;Bartlett JW;Malone IB;Schott JM;Rossor MN;Biessels GJ;DeCarli C;Fox NC;Alzheimer's Disease Neuroimaging Initiative
本研究评估了白色高信号（WMH）、脑脊液（CSF）、阿尔茨海默病（AD）病理学标志物和脑容量损失之间的关系。受试者包括197名对照者，331名轻度认知障碍（MCI）患者和146名AD患者，均接受了连续体积1.5 T MRI检查。测量CSF Aβ1-42（n = 351）和tau（n = 346）。使用边界位移积分（BSI）定量脑体积变化。我们评估了基线WMH体积和年BSI之间的相关性，调整了颅内体积。我们还对CSF亚组进行了多元回归分析，评估了WMH和Aβ1-42和/或tau与BSI的关系。对照组中WMH负荷与BSI呈正相关（p = 0.02），但与MCI或AD无关。在多变量模型中，WMH（p = 0.003）和Aβ1-42（p = 0.001）与对照组的BSI独立相关;在MCI中，Aβ1-42（p < 0.001）和tau（p = 0.04）与BSI相关。没有证据表明WMH或CSF措施对AD患者的BSI有独立影响。这些数据支持以下发现：在痴呆前阶段的AD病理学背景下，血管损伤与脑萎缩增加相关。
This study assessed relationships among white matter hyperintensities (WMH), cerebrospinal fluid (CSF), Alzheimer's disease (AD) pathology markers, and brain volume loss. Subjects included 197 controls, 331 individuals with mild cognitive impairment (MCI), and 146 individuals with AD with serial volumetric 1.5-T MRI. CSF Aβ1-42 (n = 351) and tau (n = 346) were measured. Brain volume change was quantified using the boundary shift integral (BSI). We assessed the association between baseline WMH volume and annualized BSI, adjusting for intracranial volume. We also performed multiple regression analyses in the CSF subset, assessing the relationships of WMH and Aβ1-42 and/or tau with BSI. WMH burden was positively associated with BSI in controls (p = 0.02) but not MCI or AD. In multivariable models, WMH (p = 0.003) and Aβ1-42 (p = 0.001) were independently associated with BSI in controls; in MCI Aβ1-42 (p < 0.001) and tau (p = 0.04) were associated with BSI. There was no evidence of independent effects of WMH or CSF measures on BSI in AD. These data support findings that vascular damage is associated with increased brain atrophy in the context of AD pathology in pre-dementia stages.
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影响因子：
9.9
作者：
Jack, CR;Shiung, MM;Petersen, RC
通讯作者：
Petersen, RC
影响因子：
8.3
作者：
Jeerakathil, T;Wolf, PA;DeCarli, C
通讯作者：
DeCarli, C
影响因子：
9.9
作者：
Gurol, ME;Irizarry, MC;Greenberg, SM
通讯作者：
Greenberg, SM
影响因子：
5.7
作者：
Leung, Kelvin K.;Barnes, Josephine;Ridgway, Gerard R.;Bartlett, Jonathan W.;Clarkson, Matthew J.;Macdonald, Kate;Schuff, Norbert;Fox, Nick C.;Ourselin, Sebastien
通讯作者：
Ourselin, Sebastien
DOI：
10.1523/jneurosci.3785-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative