Comment on: What is meso-zeaxanthin, and where does it come from?

Comment on: What is meso-zeaxanthin, and where does it come from?
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评论:什么是内消旋玉米黄质,它来自哪里?

DOI:
10.1038/eye.2013.257
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发表时间:
2014
期刊:
Eye (London, England)
影响因子:
--
通讯作者:
Schierle,J
Schierle,J
中科院分区:
--
文献类型:
--
作者:
Bernstein,PS;Johnson,EJ;Neuringer,M;Schalch,W;Schierle,J

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Nolan等人最近在该杂志上发表的一篇文章综述了被认为与人类视网膜中膜玉米黄质(MZ)沉积有关的生化过程。该综述的主要目的是质疑目前对视网膜MZ来源的理解,以及它仅来自叶黄素(L)。本文评价了关于MZ、L和玉米黄质(Z) 2、3的膳食来源的出版物,以及在非人灵长类动物和日本鹌鹑中补充L和Z的两项研究。5后两项研究得出结论,视网膜中的MZ仅来源于L.这篇综述对这一结论提出了质疑,但也包含了值得考虑的关键错误,详见下文。
A recent article in this journal by Nolan et al1 provides a review of biochemical processes thought to be involved in the deposition of meso-zeaxanthin (MZ) in the human retina. The main purpose of the review was to bring into question current understanding of the source of retinal MZ and that it is derived solely from lutein (L). The paper evaluates publications on the dietary sources of MZ, L, and zeaxanthin (Z) 2, 3 and on two supplementation studies with L and Z in non-human primates4 and Japanese quail. 5 These two latter studies concluded that MZ in the retina is derived solely from L. The review challenges this conclusion, but contains critical errors that should be considered, as detailed below.
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