A supplementation study in human subjects with a combination of meso-zeaxanthin, (3R,3'R)-zeaxanthin and (3R,3'R,6'R)-lutein.
A supplementation study in human subjects with a combination of meso-zeaxanthin, (3R,3'R)-zeaxanthin and (3R,3'R,6'R)-lutein.
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一项针对人类受试者的补充研究，其中含有内消旋玉米黄质、(3R,3R)-玉米黄质和(3R,3R,6R)-叶黄素。
DOI：
10.1017/s0007114508971336
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Alan N. Howard
中科院分区：
文献类型：
--
作者：
D. Thurnham;A. Tremel;Alan N. Howard
我们测量了从黄斑色素的混合物中的内消旋玉米黄质（MZ）的血液摄取，因为其在人体中的生物利用度尚未研究。招募志愿者（10名男性和9名女性）并接受一粒Lutein Plus胶囊/天。在基线、第10天和第22天采集血液。一粒胶囊含有10.8 mg叶黄素、1.2 mg（3R，3 'R）-玉米黄质和8.0 mg MZ。使用等度液相色谱法定量血浆叶黄素和总玉米黄质浓度，收集洗脱的叶黄素级分并在手性柱上重新色谱分析以评估MZ的比例。第22天每毫克剂量的血浆浓度表明，（3R，3 ′ R）-玉米黄质（0.088微摩尔/升每毫克）比叶黄素（0.056微摩尔/升每毫克）被身体更积极地保留约50%（尽管在女性中差异不显著），并且比MZ（0.026微摩尔/升每毫克）多2.5-3.0倍。第22天，女性中MZ的浓度是男性的2.5倍。叶黄素Plus中叶黄素和（3R，3 'R）-玉米黄质的血浆响应低于纯物质的文献值。也就是说，MZ的存在似乎略微抑制了它们在血浆中的摄取。β-胡萝卜素的血浆浓度在第10天降低约50%，在第22天降低约35%。总之，与（3R，3 'R）-玉米黄质相比，对MZ的较低血浆响应可能表明MZ的吸收不如（3R，3' R）-玉米黄质，但需要使用纯MZ来确认较低的血浆响应不是由于Lutein Plus中的大量叶黄素。
We measured the blood uptake of meso-zeaxanthin (MZ) from a mixture of macular pigments since its bioavailability in man has not been studied. Volunteers (ten men and nine women) were recruited and received one capsule of Lutein Plus/d. Blood was taken at baseline, day 10 and day 22. One capsule contained 10.8 mg lutein, 1.2 mg (3R,3'R)-zeaxanthin and 8.0 mg MZ. Plasma lutein and total zeaxanthin concentrations were quantified using isocratic liquid chromatography and the eluting xanthophyll fractions were collected and re-chromatographed on a chiral column to assess the proportion of MZ. Plasma concentrations per mg dose at day 22 suggested that (3R,3'R)-zeaxanthin (0.088 micromol/l per mg) was about 50 % more actively retained by the body than lutein (0.056 micromol/l per mg) (although the difference was not significant in women) and 2.5-3.0 times more than MZ (0.026 micromol/l per mg). Concentrations of MZ at day 22 were 2.5 times higher in women than men. The plasma responses from lutein and (3R,3'R)-zeaxanthin in the Lutein Plus were lower than literature values for the pure substances. That is, their uptake into plasma appeared to be slightly depressed by the presence of MZ. Plasma concentrations of beta-carotene were depressed by about 50 % at day 10 and about 35 % at day 22. In conclusion, the lower plasma response to MZ compared with (3R,3'R)-zeaxanthin probably indicates that MZ is less well absorbed than (3R,3'R)-zeaxanthin but work with pure MZ will be needed to confirm that the lower plasma response was not due to the large amount of lutein in the Lutein Plus.
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影响因子：
--
作者：
D. Friedman;S. West;B. Munoz;W. Park;James T. Deremeik;R. Massof;K. Frick;A. Broman;W. McGill
通讯作者：
D. Friedman;S. West;B. Munoz;W. Park;James T. Deremeik;R. Massof;K. Frick;A. Broman;W. McGill
选定的类胡萝卜素在人类和非灵长类动物模型的血浆、肝脏和眼组织中的转化。
DOI：
--
发表时间：
2002
期刊：
Investigative ophthalmology & visual science.
影响因子：
--
作者：
Khachik,Frederick;deMoura,FabianaF;Zhao,Da-You;Aebischer,Claude-Pierre;Bernstein,PaulS
通讯作者：
Bernstein,PaulS
影响因子：
4.2
作者：
ROCK, CL;SWENDSEID, ME;MCKEE, RW
通讯作者：
MCKEE, RW
影响因子：
4.4
作者：
Johnson, EJ;Neuringer, M;Snodderly, DM
通讯作者：
Snodderly, DM
影响因子：
5
作者：
Mares-Perlman, JA;Fisher, AI;Wright, JD
通讯作者：
Wright, JD