Sex and estrous cycle in memory for sequences of events in rats.
Sex and estrous cycle in memory for sequences of events in rats.
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DOI：
10.1037/bne0000508
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发表时间：
2022-10
影响因子：
1.9
通讯作者：
Allen, T. A.
中科院分区：
文献类型：
--
作者：
Jayachandran, M.;Langius, P.;Rego, F. Pazos;Vertes, R. P.;Allen, T. A.
记住事件顺序的能力是情景记忆的基础。虽然啮齿动物研究已经在类似情景的空间记忆任务中检查了性和发情周期，但对于依赖于时间背景表征的事件序列记忆中的这些生物变量知之甚少。我们研究了在跨物种验证的序列记忆任务的训练和测试阶段，性和动情周期在大鼠中的作用。老鼠接受了在线性轨道两端传递的两个四气味序列记忆任务的训练。训练分六个连续阶段进行，从学习刺入鼻孔≥1.2秒开始；最终通过将鼻子放在端口中 ≥1 秒（对于顺序气味）和 < 1 秒（对于无序气味）来证明序列记忆。对性别和发情周期（发情前期、发情期、发情后期、发情间期）的表现进行分析，后者由每日阴道灌洗的细胞组成决定。我们没有发现渐近序列记忆表现存在性别差异的证据，这与人类执行类似任务类似。同样，在整个发情周期的表现上也没有发现差异。需要注意的是，雄性在使用 3 种气味序列进行训练时会更快地获得乱序试验，但这种明显的优势并没有延续到 4 种气味序列中。此外，雄性的刺探时间总体较短，这似乎与总体反应抑制的降低相一致，因为它们的发生与序列要求无关。总之，这些结果表明性别和动情周期并不是序列记忆能力的主要因素。
The ability to remember sequences of events is fundamental to episodic memory. While rodent studies have examined sex and estrous cycle in episodic-like spatial memory tasks, little is known about these biological variables in memory for sequences of events that depend on representations of temporal context. We investigated the role of sex and estrous cycle in rats during training and testing stages of a cross-species validated sequence memory task. Rats were trained on a two four-odor sequence memory task delivered on opposite ends of a linear track. Training occurred in six successive stages starting with learning to poke in a nose-port for ≥1.2s; eventually demonstrating sequence memory by holding their nose in the port ≥1s for in-sequence odors and <1s for out-of-sequence odors. Performance was analyzed across sex and estrous cycle (proestrus, estrus, metestrus, diestrus), the latter being determined by cellular composition of a daily vaginal lavage. We found no evidence of sex differences in asymptotic sequence memory performance, similar to humans performing an analogous task. Likewise, no differences were found in performance across the estrous cycle. Some caveats are that males acquired out-of-sequence trials faster during training with a 3-odor sequence, but this apparent advantage did not carry over to the 4-odor sequence. Additionally, males had shorter poke times overall which seem consistent with a decreased overall response inhibition because they occurred regardless of sequence demands. Together, these results suggest sex and estrous cycle are not major factors in sequence memory capacities.
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